PMID- 8356453
OWN - NLM
STAT- MEDLINE
DCOM- 19930921
LR  - 20221130
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 261
IP  - 5125
DP  - 1993 Aug 27
TI  - Genotypic and phenotypic characterization of HIV-1 patients with primary 
      infection.
PG  - 1179-81
AB  - Better characterization of human immunodeficiency virus-type 1 (HIV-1) in 
      patients with primary infection has important implications for the development of 
      an acquired immunodeficiency syndrome (AIDS) vaccine because vaccine strategies 
      should target viral isolates with the properties of transmitted viruses. In five 
      HIV-1 seroconverters, the viral phenotype was found to be uniformly 
      macrophage-tropic and non-syncytium-inducing. Furthermore, the viruses were 
      genotypically homogeneous within each patient, but a common signature sequence 
      was not discernible among transmitted viruses. In the two cases where the sexual 
      partners were also studied, the sequences of the transmitted viruses matched best 
      with minor variants in the blood of the transmitters. There was also a stronger 
      pressure to conserve sequences in gp120 than in gp41, nef, and p17, suggesting 
      that a selective mechanism is involved in transmission.
FAU - Zhu, T
AU  - Zhu T
AD  - Aaron Diamond AIDS Research Center, New York University School of Medicine, NY 
      10016.
FAU - Mo, H
AU  - Mo H
FAU - Wang, N
AU  - Wang N
FAU - Nam, D S
AU  - Nam DS
FAU - Cao, Y
AU  - Cao Y
FAU - Koup, R A
AU  - Koup RA
FAU - Ho, D D
AU  - Ho DD
LA  - eng
SI  - GENBANK/L21224
SI  - GENBANK/L21225
SI  - GENBANK/L21226
SI  - GENBANK/L21227
SI  - GENBANK/L21228
SI  - GENBANK/L21229
SI  - GENBANK/L21230
SI  - GENBANK/L21231
SI  - GENBANK/L21232
SI  - GENBANK/L21233
SI  - GENBANK/L21234
SI  - GENBANK/L21235
SI  - GENBANK/L21236
SI  - GENBANK/L21237
SI  - GENBANK/L21238
SI  - GENBANK/L21239
SI  - GENBANK/L21240
SI  - GENBANK/L21241
SI  - GENBANK/L21242
SI  - GENBANK/L21243
SI  - GENBANK/L21244
SI  - GENBANK/L21245
SI  - GENBANK/L21246
SI  - GENBANK/L21247
SI  - GENBANK/L21248
SI  - GENBANK/L21249
SI  - GENBANK/L21250
SI  - GENBANK/L21251
SI  - GENBANK/L21252
SI  - GENBANK/L21253
GR  - AI24030/AI/NIAID NIH HHS/United States
GR  - AI25541/AI/NIAID NIH HHS/United States
GR  - AI27742/AI/NIAID NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Gene Products, gag)
RN  - 0 (HIV Antigens)
RN  - 0 (HIV Envelope Protein gp120)
RN  - 0 (HIV Envelope Protein gp41)
RN  - 0 (Viral Proteins)
RN  - 0 (gag Gene Products, Human Immunodeficiency Virus)
RN  - 0 (p17 protein, Human Immunodeficiency Virus Type 1)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cell Line
MH  - Female
MH  - Gene Products, gag/chemistry/genetics
MH  - Genes, Viral
MH  - Genotype
MH  - Giant Cells/physiology
MH  - HIV Antigens/chemistry/genetics
MH  - HIV Envelope Protein gp120/chemistry/*genetics
MH  - HIV Envelope Protein gp41/chemistry/genetics
MH  - HIV Infections/*microbiology/transmission
MH  - HIV Seropositivity/microbiology
MH  - HIV-1/chemistry/*genetics/*physiology
MH  - Humans
MH  - Macrophages
MH  - Male
MH  - Molecular Sequence Data
MH  - Phenotype
MH  - Sequence Alignment
MH  - Sexual Partners
MH  - *Viral Proteins
MH  - Virus Replication
MH  - gag Gene Products, Human Immunodeficiency Virus
EDAT- 1993/08/27 00:00
MHDA- 1993/08/27 00:01
CRDT- 1993/08/27 00:00
PHST- 1993/08/27 00:00 [pubmed]
PHST- 1993/08/27 00:01 [medline]
PHST- 1993/08/27 00:00 [entrez]
AID - 10.1126/science.8356453 [doi]
PST - ppublish
SO  - Science. 1993 Aug 27;261(5125):1179-81. doi: 10.1126/science.8356453.