PMID- 8421498
OWN - NLM
STAT- MEDLINE
DCOM- 19930217
LR  - 20220321
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 361
IP  - 6407
DP  - 1993 Jan 7
TI  - Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin.
PG  - 82-5
AB  - Langerhans cells (LC) are the principal accessory cells present in epidermis. 
      Because LC have limited capacity for self-renewal, epidermis is continually 
      repopulated by as-yet uncharacterized bone marrow-derived LC progenitors. In 
      addition, although LC persist in epidermis for extended periods, LC are induced 
      to migrate from skin to regional lymph nodes after antigen exposure. To begin to 
      elucidate mechanisms involved in LC trafficking, we characterized LC-keratinocyte 
      (KC) interactions. Here we report that fresh murine LC express cadherins, and 
      that LC adhere to KC in vitro through E-cadherin. Cultured LC (which may bear a 
      phenotypic and functional relationship to LC that have migrated to lymph nodes) 
      express lower levels of E-cadherin and exhibit decreased affinity for KC. These 
      results suggest that expression of E-cadherin by LC promotes persistence of these 
      cells in epidermis, and that cadherins may play important and unanticipated roles 
      in interactions between leukocytes and epithelia.
FAU - Tang, A
AU  - Tang A
AD  - Dermatology Branch, National Cancer Institute, Bethesda, Maryland 20892.
FAU - Amagai, M
AU  - Amagai M
FAU - Granger, L G
AU  - Granger LG
FAU - Stanley, J R
AU  - Stanley JR
FAU - Udey, M C
AU  - Udey MC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Cadherins)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal
MH  - Base Sequence
MH  - Cadherins/*physiology
MH  - Cell Adhesion
MH  - Cells, Cultured
MH  - Flow Cytometry
MH  - Keratinocytes/*physiology
MH  - L Cells/physiology
MH  - Langerhans Cells/*physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Sequence Data
EDAT- 1993/01/07 00:00
MHDA- 1993/01/07 00:01
CRDT- 1993/01/07 00:00
PHST- 1993/01/07 00:00 [pubmed]
PHST- 1993/01/07 00:01 [medline]
PHST- 1993/01/07 00:00 [entrez]
AID - 10.1038/361082a0 [doi]
PST - ppublish
SO  - Nature. 1993 Jan 7;361(6407):82-5. doi: 10.1038/361082a0.