PMID- 8453669
OWN - NLM
STAT- MEDLINE
DCOM- 19930421
LR  - 20220409
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 72
IP  - 5
DP  - 1993 Mar 12
TI  - A novel moesin-, ezrin-, radixin-like gene is a candidate for the 
      neurofibromatosis 2 tumor suppressor.
PG  - 791-800
AB  - Neurofibromatosis 2 (NF2) is a dominantly inherited disorder characterized by the 
      occurrence of bilateral vestibular schwannomas and other central nervous system 
      tumors including multiple meningiomas. Genetic linkage studies and investigations 
      of both sporadic and familial tumors suggest that NF2 is caused by inactivation 
      of a tumor suppressor gene in chromosome 22q12. We have identified a candidate 
      gene for the NF2 tumor suppressor that has suffered nonoverlapping deletions in 
      DNA from two independent NF2 families and alterations in meningiomas from two 
      unrelated NF2 patients. The candidate gene encodes a 587 amino acid protein with 
      striking similarity to several members of a family of proteins proposed to link 
      cytoskeletal components with proteins in the cell membrane. The NF2 gene may 
      therefore constitute a novel class of tumor suppressor gene.
FAU - Trofatter, J A
AU  - Trofatter JA
AD  - Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown.
FAU - MacCollin, M M
AU  - MacCollin MM
FAU - Rutter, J L
AU  - Rutter JL
FAU - Murrell, J R
AU  - Murrell JR
FAU - Duyao, M P
AU  - Duyao MP
FAU - Parry, D M
AU  - Parry DM
FAU - Eldridge, R
AU  - Eldridge R
FAU - Kley, N
AU  - Kley N
FAU - Menon, A G
AU  - Menon AG
FAU - Pulaski, K
AU  - Pulaski K
AU  - et al.
LA  - eng
SI  - GENBANK/L09219
SI  - GENBANK/L09220
SI  - GENBANK/L09221
SI  - GENBANK/L09222
SI  - GENBANK/L09223
SI  - GENBANK/L09224
SI  - GENBANK/L09225
SI  - GENBANK/L10382
SI  - GENBANK/L11353
SI  - GENBANK/L33709
GR  - HG00317/HG/NHGRI NIH HHS/United States
GR  - HG00672/HG/NHGRI NIH HHS/United States
GR  - NS24279/NS/NINDS NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Blood Proteins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Proteins)
RN  - 0 (ezrin)
RN  - 144131-77-1 (moesin)
RN  - 144517-21-5 (radixin)
SB  - IM
EIN - Cell. 1993 Nov 19;75(4):826. PMID: 8242753
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Blood Proteins/chemistry/genetics
MH  - Chromosome Aberrations
MH  - Chromosome Disorders
MH  - Chromosome Walking
MH  - *Cytoskeletal Proteins
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - Membrane Proteins/chemistry/genetics
MH  - *Microfilament Proteins
MH  - Molecular Sequence Data
MH  - Neurofibromatosis 2/*genetics
MH  - Phosphoproteins/chemistry/genetics
MH  - Proteins/chemistry/genetics
MH  - Sequence Homology, Amino Acid
EDAT- 1993/03/12 00:00
MHDA- 1993/03/12 00:01
CRDT- 1993/03/12 00:00
PHST- 1993/03/12 00:00 [pubmed]
PHST- 1993/03/12 00:01 [medline]
PHST- 1993/03/12 00:00 [entrez]
AID - 0092-8674(93)90406-G [pii]
AID - 10.1016/0092-8674(93)90406-g [doi]
PST - ppublish
SO  - Cell. 1993 Mar 12;72(5):791-800. doi: 10.1016/0092-8674(93)90406-g.