PMID- 8575293
OWN - NLM
STAT- MEDLINE
DCOM- 19960311
LR  - 20220215
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 121
IP  - 12
DP  - 1995 Dec
TI  - Longitudinal organization of the anterior neural plate and neural tube.
PG  - 3923-33
AB  - Over the last century, several morphological models of forebrain organization 
      have been proposed that hypothesize alternative topological solutions for the 
      relationships of the histogenic primordia. Central to all of these models are 
      their definitions of the longitudinal axis and the longitudinal organization of 
      the neural plate and neural tube. To understand the longitudinal organization of 
      the anterior brain, we have sought to identify molecular properties that are 
      continuous along the entire longitudinal axis of the embryonic CNS. In this 
      essay, we describe studies of the expression of several genes in the mouse 
      between 7.5 (presomite stage) and 10.5 days post coitum (dpc) that provide 
      evidence for the trajectory of the anterior-posterior axis and the longitudinal 
      organization of the anterior CNS. Specifically, we report that the expression of 
      noggin, sonic hedgehog and Nkx-2.2 define longitudinal columns of cells that are 
      present along the entire CNS axis. Within the forebrain, the expression of these 
      genes, as well as that of Nkx-2.1 and BF-1, are in distinct longitudinal regions 
      in the neural plate and tube. We demonstrate that the earliest longitudinal axon 
      pathways of the forebrain are spatially correlated with the longitudinal domain 
      defined by Nkx-2.2. Finally, expression of the former genes, and Otx-1 and Emx-2, 
      suggests that the cephalic neural plate is organized into molecularly distinct 
      domains delimited by longitudinal and transverse borders; these results provide a 
      foundation for defining the mechanisms that pattern the neural plate.
FAU - Shimamura, K
AU  - Shimamura K
AD  - Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, 
      University of California, San Francisco 94143-0984, USA.
FAU - Hartigan, D J
AU  - Hartigan DJ
FAU - Martinez, S
AU  - Martinez S
FAU - Puelles, L
AU  - Puelles L
FAU - Rubenstein, J L
AU  - Rubenstein JL
LA  - eng
GR  - K02 MH01046-01/MH/NIMH NIH HHS/United States
GR  - R01 MH49428/MH/NIMH NIH HHS/United States
GR  - R01 MH51561-01A1/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
SB  - IM
MH  - Animals
MH  - Central Nervous System/embryology
MH  - Gene Expression
MH  - *Genes, Homeobox
MH  - Mice
MH  - Morphogenesis/genetics
MH  - Prosencephalon/*embryology
RF  - 66
EDAT- 1995/12/01 00:00
MHDA- 1995/12/01 00:01
CRDT- 1995/12/01 00:00
PHST- 1995/12/01 00:00 [pubmed]
PHST- 1995/12/01 00:01 [medline]
PHST- 1995/12/01 00:00 [entrez]
AID - 10.1242/dev.121.12.3923 [doi]
PST - ppublish
SO  - Development. 1995 Dec;121(12):3923-33. doi: 10.1242/dev.121.12.3923.