PMID- 8581522
OWN - NLM
STAT- MEDLINE
DCOM- 19960320
LR  - 20191101
IS  - 1023-3830 (Print)
IS  - 1023-3830 (Linking)
VI  - 44
IP  - 8
DP  - 1995 Aug
TI  - Suppression of experimental allergic encephalomyelitis in the Lewis rat by the 
      matrix metalloproteinase inhibitor Ro31-9790.
PG  - 345-9
AB  - Matrix metalloproteinases (MMPs) are implicated in the tissue destruction 
      associated with inflammatory demyelinating diseases such as multiple sclerosis. 
      The effect of a hydroxamate inhibitor of MMPs, Ro31-9790, on inflammatory 
      demyelination was assessed in two acute models of experimental allergic 
      encephalomyelitis (EAE). Daily intraperitoneal injections of Ro31-9790 (50 mg 
      kg-1), beginning either at the time of disease induction or from day 3 post 
      induction, significantly reduced the clinical severity of adoptively transferred 
      EAE. Administration of the inhibitor from the day of induction of active EAE 
      prevented disease onset in 9/10 animals. However, in a repeat study, in which 
      clinical disease was much more severe in the vesicle treated animals, the 
      inhibitor was less effective. Clinical signs and CNS histopathology correlated 
      well, with greater numbers of inflammatory lesions associated with increased 
      disease severity. The present study confirms a role for then MMP cascade in 
      inflammation in EAE.
FAU - Hewson, A K
AU  - Hewson AK
AD  - Multiple Sclerosis Laboratory, Institute of Neurology, London, UK.
FAU - Smith, T
AU  - Smith T
FAU - Leonard, J P
AU  - Leonard JP
FAU - Cuzner, M L
AU  - Cuzner ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Inflamm Res
JT  - Inflammation research : official journal of the European Histamine Research 
      Society ... [et al.]
JID - 9508160
RN  - 0 (Hydroxamic Acids)
RN  - 0 (Myelin Basic Protein)
RN  - 0 (Protease Inhibitors)
RN  - 0 (Ro 31-9790)
RN  - EC 3.4.24.- (Metalloendopeptidases)
SB  - IM
MH  - Animals
MH  - Encephalomyelitis, Autoimmune, Experimental/*drug therapy/pathology
MH  - Female
MH  - *Hydroxamic Acids
MH  - Immunotherapy, Adoptive
MH  - Metalloendopeptidases/*antagonists & inhibitors
MH  - Myelin Basic Protein/immunology
MH  - Protease Inhibitors/*therapeutic use
MH  - Rats
MH  - Rats, Inbred Lew
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
AID - 10.1007/BF01796266 [doi]
PST - ppublish
SO  - Inflamm Res. 1995 Aug;44(8):345-9. doi: 10.1007/BF01796266.