PMID- 8592733
OWN - NLM
STAT- MEDLINE
DCOM- 19960401
LR  - 20220316
IS  - 0031-9333 (Print)
IS  - 0031-9333 (Linking)
VI  - 76
IP  - 1
DP  - 1996 Jan
TI  - Cellular changes involved in conversion of normal to malignant breast: importance 
      of the stromal reaction.
PG  - 69-125
AB  - Reciprocal interactions between epithelium and mesenchyme mediate crucial aspects 
      of embryonic development and direct the coordinated organogenesis, correct 
      spatial orientation, and the timely expression of functional activity consistent 
      with physiological demands. The mesenchymal equivalent in the adult organism is 
      the stroma, i.e., the loose connective tissue that is separated from the 
      epithelial compartment by an intact basement membrane. In carcinomas, the 
      cellular organization is dramatically changed, and the stroma is extensively 
      modified. The basement membrane is penetrated in a process of degradation and/or 
      decreased synthesis, and direct contact between tumor cells and the surrounding 
      stroma coincides with neovascularization, inflammatory cell influx, and extensive 
      remodeling of extracellular matrix. In this review, we highlight our current 
      knowledge of tumor cell stromal interactions in the mammary gland with particular 
      emphasis on cellular origins and functional phenotypes. We focus both on normal 
      mammary gland and breast tumors and on culture systems developed to dissect 
      individual aspects of cell-cell and cell-extracellular matrix interactions.
FAU - Ronnov-Jessen, L
AU  - Ronnov-Jessen L
AD  - Structural Cell Biology Unit, Panum Institute, University of Copenhagen, Denmark.
FAU - Petersen, O W
AU  - Petersen OW
FAU - Bissell, M J
AU  - Bissell MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Physiol Rev
JT  - Physiological reviews
JID - 0231714
SB  - IM
MH  - Animals
MH  - Breast/cytology/*pathology
MH  - Breast Neoplasms/metabolism/*pathology
MH  - *Cell Transformation, Neoplastic
MH  - Humans
MH  - Stromal Cells/*pathology
RF  - 630
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 1996/01/01 00:00
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
PHST- 1996/01/01 00:00 [entrez]
AID - 10.1152/physrev.1996.76.1.69 [doi]
PST - ppublish
SO  - Physiol Rev. 1996 Jan;76(1):69-125. doi: 10.1152/physrev.1996.76.1.69.