PMID- 8599114
OWN - NLM
STAT- MEDLINE
DCOM- 19960425
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 271
IP  - 5255
DP  - 1996 Mar 15
TI  - HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral 
      generation time.
PG  - 1582-6
AB  - A new mathematical model was used to analyze a detailed set of human 
      immunodeficiency virus-type 1 (HIV-1) viral load data collected from five 
      infected individuals after the administration of a potent inhibitor of HIV-1 
      protease. Productively infected cells were estimated to have, on average, a 
      life-span of 2.2 days (half-life t 1/2 = 1.6 days), and plasma virions were 
      estimated to have a mean life-span of 0.3 days (t 1/2 = 0.24 days). The estimated 
      average total HIV-1 production was 10.3 x 10(9) virions per day, which is 
      substantially greater than previous minimum estimates. The results also suggest 
      that the minimum duration of the HIV-1 life cycle in vivo is 1.2 days on average, 
      and that the average HIV-1 generation time--defined as the time from release of a 
      virion until it infects another cell and causes the release of a new generation 
      of viral particles--is 2.6 days. These findings on viral dynamics provide not 
      only a kinetic picture of HIV-1 pathogenesis, but also theoretical principles to 
      guide the development of treatment strategies.
FAU - Perelson, A S
AU  - Perelson AS
AD  - Theoretical Division, Los Alamos National Laboratory, NM 87545, USA.
FAU - Neumann, A U
AU  - Neumann AU
FAU - Markowitz, M
AU  - Markowitz M
FAU - Leonard, J M
AU  - Leonard JM
FAU - Ho, D D
AU  - Ho DD
LA  - eng
GR  - AI27742/AI/NIAID NIH HHS/United States
GR  - N01 AI45218/AI/NIAID NIH HHS/United States
GR  - RR06555/RR/NCRR NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antiviral Agents)
RN  - 0 (HIV Protease Inhibitors)
RN  - 0 (RNA, Viral)
RN  - 0 (Thiazoles)
RN  - HG18B9YRS7 (Valine)
RN  - O3J8G9O825 (Ritonavir)
SB  - IM
MH  - Antiviral Agents/administration & dosage/therapeutic use
MH  - CD4 Lymphocyte Count
MH  - CD4-Positive T-Lymphocytes/*cytology/*virology
MH  - Cell Survival
MH  - HIV Infections/drug therapy/*virology
MH  - HIV Protease Inhibitors/administration & dosage/therapeutic use
MH  - HIV-1/drug effects/*physiology
MH  - Half-Life
MH  - Humans
MH  - Kinetics
MH  - Models, Biological
MH  - RNA, Viral/blood
MH  - Regression Analysis
MH  - Ritonavir
MH  - Thiazoles/administration & dosage/therapeutic use
MH  - Valine/administration & dosage/analogs & derivatives/therapeutic use
MH  - Viremia
MH  - Virion/drug effects/*physiology
MH  - Virus Replication
EDAT- 1996/03/15 00:00
MHDA- 1996/03/15 00:01
CRDT- 1996/03/15 00:00
PHST- 1996/03/15 00:00 [pubmed]
PHST- 1996/03/15 00:01 [medline]
PHST- 1996/03/15 00:00 [entrez]
AID - 10.1126/science.271.5255.1582 [doi]
PST - ppublish
SO  - Science. 1996 Mar 15;271(5255):1582-6. doi: 10.1126/science.271.5255.1582.