PMID- 8603594
OWN - NLM
STAT- MEDLINE
DCOM- 19960514
LR  - 20091119
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 137
IP  - 3
DP  - 1996 Mar
TI  - The Drosophila insulin receptor is required for normal growth.
PG  - 846-56
AB  - Drosophila contain an insulin receptor homologue, encoded by the inr gene located 
      at position 93E4-5 on the third chromosome. The receptor protein is strikingly 
      homologous to the human receptor, exhibiting the same alpha2beta2 subunit 
      structure and containing a ligand- activated tyrosine kinase in its cytoplasmic 
      domain. Chemical mutagenesis was used to induce mutations in the inr gene and six 
      independent mutations that lead to a loss of expression or function of the 
      receptor protein were identified. These mutations are recessive, embryonic, or 
      early larval lethals, but some alleles exhibit heteroallelic complementation to 
      yield adults with a severe developmental delay (10 days), growth-deficiency, 
      female-sterile phenotype. Interestingly, the severity of the mutant phenotype 
      correlates with biochemical measures of loss of function of the receptor tyrosine 
      kinase. The growth deficiency appears to be due to a reduction in cell number, 
      suggesting a role for inr in regulation of cell proliferation during development. 
      The phenotype is reminiscent of those seen in syndromes of insulin-resistance or 
      IGF-I and IGF-I receptor deficiencies in higher organisms, suggesting a conserved 
      function for this growth factor family in the regulation of growth and body size.
FAU - Chen, C
AU  - Chen C
AD  - Department of Anatomy and Cell Biology, State University of New York, Brooklyn, 
      New York 11203, USA.
FAU - Jack, J
AU  - Jack J
FAU - Garofalo, R S
AU  - Garofalo RS
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - EC 2.7.10.1 (Receptor, Insulin)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Division
MH  - Drosophila/*growth & development/physiology
MH  - Female
MH  - Mutation
MH  - Receptor, Insulin/*physiology
EDAT- 1996/03/01 00:00
MHDA- 1996/03/01 00:01
CRDT- 1996/03/01 00:00
PHST- 1996/03/01 00:00 [pubmed]
PHST- 1996/03/01 00:01 [medline]
PHST- 1996/03/01 00:00 [entrez]
AID - 10.1210/endo.137.3.8603594 [doi]
PST - ppublish
SO  - Endocrinology. 1996 Mar;137(3):846-56. doi: 10.1210/endo.137.3.8603594.