PMID- 8606003
OWN - NLM
STAT- MEDLINE
DCOM- 19960517
LR  - 20190524
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 173
IP  - 2
DP  - 1996 Feb 1
TI  - Positional information along the dorsal-ventral axis of the Drosophila eye: 
      graded expression of the four-jointed gene.
PG  - 428-46
AB  - Several observations suggest that developing ommatidia in the Drosophila eye have 
      distinct dorsal-ventral (d-v) positional identities, despite their morphological 
      uniformity. To identify molecular differences along the d-v axis of the eye, we 
      carried out a systematic screen for P-element insertions that show nonuniform 
      reporter gene expression along this axis. We identified P-element insertions in 
      which lacZ expression is activated in dorsal, ventral, or equatorial regions of 
      the disc. These patterns of transcriptional enhancer activity are established 
      early in disc development and are maintained in a size invariant manner during 
      disc growth. Several insertions with an equatorial-to-polar gradient of lacZ 
      expression disrupt the four-jointed (fj) gene which is required for proper leg, 
      wing, and eye development. The fj cDNA sequence includes a presumptive internal 
      signal sequence, indicating that fj encodes a cell surface or secreted protein. 
      Analysis of the fj phenotype and expression pattern in the leg suggests that fj 
      is required for cell-cell signaling during disc development.
FAU - Brodsky, M H
AU  - Brodsky MH
AD  - Howard Hughes Medical Institute, Department of Brain and Cognitive Sciences, 
      Massachusetts Institute of Technology, Cambridge 02139, USA.
FAU - Steller, H
AU  - Steller H
LA  - eng
SI  - GENBANK/U44904
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (DNA Transposable Elements)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (fj protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA Transposable Elements/genetics
MH  - Drosophila/genetics/*growth & development
MH  - *Drosophila Proteins
MH  - Enhancer Elements, Genetic/genetics
MH  - Extremities/growth & development
MH  - Eye/growth & development
MH  - Female
MH  - *Gene Expression Regulation, Developmental
MH  - Genes, Insect/genetics
MH  - Genes, Reporter/genetics
MH  - Male
MH  - Membrane Glycoproteins/chemistry/*genetics
MH  - Molecular Sequence Data
MH  - Mutation/physiology
MH  - RNA, Messenger/analysis
MH  - Sequence Analysis, DNA
MH  - Transcription, Genetic
MH  - Wings, Animal/growth & development
EDAT- 1996/02/01 00:00
MHDA- 1996/02/01 00:01
CRDT- 1996/02/01 00:00
PHST- 1996/02/01 00:00 [pubmed]
PHST- 1996/02/01 00:01 [medline]
PHST- 1996/02/01 00:00 [entrez]
AID - S0012-1606(96)90038-X [pii]
AID - 10.1006/dbio.1996.0038 [doi]
PST - ppublish
SO  - Dev Biol. 1996 Feb 1;173(2):428-46. doi: 10.1006/dbio.1996.0038.