PMID- 8608595
OWN - NLM
STAT- MEDLINE
DCOM- 19960524
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 84
IP  - 3
DP  - 1996 Feb 9
TI  - Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein 
      similar to the mammalian STATs.
PG  - 411-9
AB  - We have identified a putative Drosophila STAT protein named Marelle that exhibits 
      mutant phenotypes identical to mutations in the Hopscotch/JAK kinase. We show 
      that a reduction in the amount of marelle gene activity suppresses the phenotype 
      associated with a gain-of-function mutation in hopscotch and enhances the 
      phenotype associated with a weak hopscotch mutation. We propose that Hopscotch 
      activates Marelle to regulate transcription of target genes such as the pair rule 
      gene even-skipped. Our results demonstrate the existence of an invertebrate 
      JAK/STAT system.
FAU - Hou, X S
AU  - Hou XS
AD  - Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 
      02115, USA.
FAU - Melnick, M B
AU  - Melnick MB
FAU - Perrimon, N
AU  - Perrimon N
LA  - eng
SI  - GENBANK/U40070
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 9007-49-2 (DNA)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (Janus Kinases)
RN  - EC 2.7.10.2 (hop protein, Drosophila)
SB  - IM
EIN - Cell 1996 Apr 19;85(2):following 290
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA/genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Drosophila/embryology/*genetics
MH  - Drosophila Proteins
MH  - Female
MH  - Genes, Insect
MH  - Janus Kinases
MH  - Male
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Phenotype
MH  - Protein-Tyrosine Kinases/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction/genetics
MH  - Suppression, Genetic
MH  - Trans-Activators/*genetics
MH  - Transcription Factors
EDAT- 1996/02/09 00:00
MHDA- 1996/02/09 00:01
CRDT- 1996/02/09 00:00
PHST- 1996/02/09 00:00 [pubmed]
PHST- 1996/02/09 00:01 [medline]
PHST- 1996/02/09 00:00 [entrez]
AID - S0092-8674(00)81286-6 [pii]
AID - 10.1016/s0092-8674(00)81286-6 [doi]
PST - ppublish
SO  - Cell. 1996 Feb 9;84(3):411-9. doi: 10.1016/s0092-8674(00)81286-6.