PMID- 8608598
OWN - NLM
STAT- MEDLINE
DCOM- 19960524
LR  - 20220331
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 84
IP  - 3
DP  - 1996 Feb 9
TI  - Targeted disruption of the mouse Stat1 gene results in compromised innate 
      immunity to viral disease.
PG  - 443-50
AB  - The STAT1 transcription factor is activated in response to many cytokines and 
      growth factors. To study the requirement for STAT1 in vivo, we disrupted the 
      Stat1 gene in embryonic stem (ES) cells and in mice. Stat1(-1-)ES cells were 
      unresponsive to interferon (IFN), but retained responsiveness to leukemia 
      inhibitory factor (LIF) and remained LIF dependent for undifferentiated growth. 
      Stat1(-1-1) animals were born at normal frequencies and displayed no gross 
      developmental defects. However, these animals failed to thrive and were extremely 
      susceptible to viral disease. Cells and tissues from Stat1(-1-) mice were 
      unresponsive to IFN, but remained responsive to all other cytokines tested. Thus, 
      STAT1 appears to be specific for IFN pathways that are essential for viability in 
      the face of otherwise innocuous pathogens.
FAU - Durbin, J E
AU  - Durbin JE
AD  - Department of Pathology, New York University School of Medicine, New York 10016, 
      USA.
FAU - Hackenmiller, R
AU  - Hackenmiller R
FAU - Simon, M C
AU  - Simon MC
FAU - Levy, D E
AU  - Levy DE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Cytokines)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Growth Inhibitors)
RN  - 0 (Interleukin-6)
RN  - 0 (Leukemia Inhibitory Factor)
RN  - 0 (Lif protein, mouse)
RN  - 0 (Lymphokines)
RN  - 0 (STAT1 Transcription Factor)
RN  - 0 (Stat1 protein, mouse)
RN  - 0 (Trans-Activators)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Animals
MH  - Cytokines/pharmacology
MH  - DNA-Binding Proteins/*genetics/*immunology
MH  - Female
MH  - Gene Targeting
MH  - Growth Inhibitors/pharmacology
MH  - Interferons/pharmacology
MH  - *Interleukin-6
MH  - Leukemia Inhibitory Factor
MH  - Lymphokines/pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Opportunistic Infections/genetics/immunology
MH  - Phenotype
MH  - STAT1 Transcription Factor
MH  - Signal Transduction/genetics/immunology
MH  - Stem Cells/immunology
MH  - Trans-Activators/*genetics/*immunology
MH  - Vesicular stomatitis Indiana virus/immunology/pathogenicity
MH  - Virus Diseases/*genetics/*immunology
EDAT- 1996/02/09 00:00
MHDA- 1996/02/09 00:01
CRDT- 1996/02/09 00:00
PHST- 1996/02/09 00:00 [pubmed]
PHST- 1996/02/09 00:01 [medline]
PHST- 1996/02/09 00:00 [entrez]
AID - S0092-8674(00)81289-1 [pii]
AID - 10.1016/s0092-8674(00)81289-1 [doi]
PST - ppublish
SO  - Cell. 1996 Feb 9;84(3):443-50. doi: 10.1016/s0092-8674(00)81289-1.