PMID- 8614832
OWN - NLM
STAT- MEDLINE
DCOM- 19960606
LR  - 20210108
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 272
IP  - 5262
DP  - 1996 May 3
TI  - Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 
      WAF1/CIP1 mediated by STAT1.
PG  - 719-22
AB  - Signal transducers and activators of transcription (STAT) proteins can be 
      conditionally activated in response to epidermal growth factor (EGF) and 
      interferon (IFN)-gamma. STAT activation was correlated with cell growth 
      inhibition in response to EGF and IFN-gamma. Activated STAT proteins specifically 
      recognized the conserved STAT-responsive elements in the promoter of the gene 
      encoding the cyclin-dependent kinase (CDK) inhibitor p21 WAF1/CIP1 and regulated 
      the induction of p21 messenger RNA. IFN-gamma did not inhibit the growth of U3A 
      cells, which are deficient in STAT1, but did inhibit the growth of U3A cells into 
      which STAT1 alpha was reintroduced. Thus, STAT1 protein is essential for cell 
      growth suppression in response to IFN-gamma. The STAT signaling pathway appears 
      to negatively regulate the cell cycle by inducing CDK inhibitors in response to 
      cytokines.
FAU - Chin, Y E
AU  - Chin YE
AD  - Department of Pathology, Yale University School of Medicine, New Haven, CT 
      06520-8023, USA.
FAU - Kitagawa, M
AU  - Kitagawa M
FAU - Su, W C
AU  - Su WC
FAU - You, Z H
AU  - You ZH
FAU - Iwamoto, Y
AU  - Iwamoto Y
FAU - Fu, X Y
AU  - Fu XY
LA  - eng
GR  - R01 AI34522/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (CDKN1A protein, human)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p21)
RN  - 0 (Cyclins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (STAT1 Transcription Factor)
RN  - 0 (STAT1 protein, human)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
RN  - 0 (Trans-Activators)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Base Sequence
MH  - Binding Sites
MH  - *Cell Division/drug effects
MH  - Cell Line
MH  - Cyclin-Dependent Kinase Inhibitor p21
MH  - Cyclins/biosynthesis/*genetics
MH  - DNA/biosynthesis
MH  - DNA-Binding Proteins/metabolism/*physiology
MH  - Epidermal Growth Factor/pharmacology
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Interferon-gamma/pharmacology
MH  - Molecular Sequence Data
MH  - Promoter Regions, Genetic
MH  - RNA, Messenger/genetics/metabolism
MH  - STAT1 Transcription Factor
MH  - STAT3 Transcription Factor
MH  - *Signal Transduction
MH  - Trans-Activators/metabolism/*physiology
MH  - Transfection
MH  - Tumor Cells, Cultured
EDAT- 1996/05/03 00:00
MHDA- 1996/05/03 00:01
CRDT- 1996/05/03 00:00
PHST- 1996/05/03 00:00 [pubmed]
PHST- 1996/05/03 00:01 [medline]
PHST- 1996/05/03 00:00 [entrez]
AID - 10.1126/science.272.5262.719 [doi]
PST - ppublish
SO  - Science. 1996 May 3;272(5262):719-22. doi: 10.1126/science.272.5262.719.