PMID- 8616842
OWN - NLM
STAT- MEDLINE
DCOM- 19960612
LR  - 20091119
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 56
IP  - 9
DP  - 1996 May 1
TI  - Expression of vascular endothelial growth factor, its receptor, and other 
      angiogenic factors in human breast cancer.
PG  - 2013-6
AB  - Angiogenesis is essential for the growth and metastasis of solid tumors. In this 
      study, we examined gene expression of vascular endothelial growth factor (VEGF); 
      its receptor, flt-1; basic fibroblast growth factor; and transforming growth 
      factors (TGFs) alpha and beta in 18 paired cases of human breast carcinomas and 
      the adjacent nonneoplastic tissues. In all of the paired cases, VEGF expression 
      was markedly increased in the carcinomas. In contrast, an insignificant 
      difference was observed in the expression of flt-1, basic fibroblast growth 
      factor, TGF-alpha, and TGF-beta between the malignant breast tissue and the 
      nonneoplastic counterpart. Immunostaining showed variable VEGF positivity of the 
      malignant cells, whereas the nonneoplastic breast epithelial cells were negative. 
      The findings of this study suggest that VEGF is an important angiogenic factor in 
      human breast cancer.
FAU - Yoshiji, H
AU  - Yoshiji H
AD  - Tumor Biology and Carcinogenesis Section, National Cancer Institute, NIH, 
      Bethesda, Maryland 20892, USA.
FAU - Gomez, D E
AU  - Gomez DE
FAU - Shibuya, M
AU  - Shibuya M
FAU - Thorgeirsson, U P
AU  - Thorgeirsson UP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Angiogenesis Inducing Agents)
RN  - 0 (Endothelial Growth Factors)
RN  - 0 (Lymphokines)
RN  - 0 (Receptors, Growth Factor)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factors)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptors, Vascular Endothelial Growth Factor)
SB  - IM
MH  - Angiogenesis Inducing Agents/*biosynthesis/genetics
MH  - Breast Neoplasms/blood supply/genetics/*metabolism
MH  - Endothelial Growth Factors/*biosynthesis/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Lymphokines/*biosynthesis/genetics
MH  - Neovascularization, Pathologic/*metabolism
MH  - Receptor Protein-Tyrosine Kinases/*biosynthesis/genetics
MH  - Receptors, Growth Factor/*biosynthesis/genetics
MH  - Receptors, Vascular Endothelial Growth Factor
MH  - Vascular Endothelial Growth Factor A
MH  - Vascular Endothelial Growth Factors
EDAT- 1996/05/01 00:00
MHDA- 1996/05/01 00:01
CRDT- 1996/05/01 00:00
PHST- 1996/05/01 00:00 [pubmed]
PHST- 1996/05/01 00:01 [medline]
PHST- 1996/05/01 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1996 May 1;56(9):2013-6.