PMID- 8622955
OWN - NLM
STAT- MEDLINE
DCOM- 19960618
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 93
IP  - 8
DP  - 1996 Apr 16
TI  - Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central 
      nervous system and blocks definitive hematopoiesis.
PG  - 3444-9
AB  - The CBFA2 (AML1) gene encodes a DNA-binding subunit of the heterodimeric 
      core-binding factor. The CBFA2 gene is disrupted by the (8;21), (3;21), and 
      (12;21) chromosomal translocations associated with leukemias and myelodysplasias 
      in humans. Mice lacking a CBF alpha 2 protein capable of binding DNA die between 
      embryonic days 11.5 and 12.5 due to hemorrhaging in the central nervous system 
      (CNS), at the nerve/CNS interfaces of cranial and spinal nerves, and in 
      somitic/intersomitic regions along the presumptive spinal cord. Hemorrhaging is 
      preceded by symmetric, bilateral necrosis in these regions. Definitive 
      erythropoiesis and myelopoiesis do not occur in Cbfa2-deficient embryos, and 
      disruption of one copy of the Cbfa2 gene significantly reduces the number of 
      progenitors for erythroid and myeloid cells.
FAU - Wang, Q
AU  - Wang Q
AD  - Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.
FAU - Stacy, T
AU  - Stacy T
FAU - Binder, M
AU  - Binder M
FAU - Marin-Padilla, M
AU  - Marin-Padilla M
FAU - Sharpe, A H
AU  - Sharpe AH
FAU - Speck, N A
AU  - Speck NA
LA  - eng
GR  - CA58343/CA/NCI NIH HHS/United States
GR  - IPO30AR42689/AR/NIAMS NIH HHS/United States
GR  - NS-22897/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RUNX1 protein, human)
RN  - 0 (Runx1 protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Central Nervous System Diseases/*genetics/pathology
MH  - Core Binding Factor Alpha 2 Subunit
MH  - DNA Primers/genetics
MH  - DNA, Complementary/genetics
MH  - *DNA-Binding Proteins
MH  - Erythropoiesis/genetics
MH  - Female
MH  - Fetal Death/genetics
MH  - Gene Targeting
MH  - Hematopoiesis/*genetics
MH  - Hemorrhage/genetics
MH  - Humans
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Necrosis
MH  - Neoplasm Proteins/*genetics
MH  - Pregnancy
MH  - *Proto-Oncogene Proteins
MH  - *Proto-Oncogenes
MH  - Transcription Factors/*genetics
PMC - PMC39628
EDAT- 1996/04/16 00:00
MHDA- 1996/04/16 00:01
PMCR- 1996/10/16
CRDT- 1996/04/16 00:00
PHST- 1996/04/16 00:00 [pubmed]
PHST- 1996/04/16 00:01 [medline]
PHST- 1996/04/16 00:00 [entrez]
PHST- 1996/10/16 00:00 [pmc-release]
AID - 10.1073/pnas.93.8.3444 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3444-9. doi: 10.1073/pnas.93.8.3444.