PMID- 8638126
OWN - NLM
STAT- MEDLINE
DCOM- 19960705
LR  - 20230108
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 272
IP  - 5264
DP  - 1996 May 17
TI  - Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex 
      assembly.
PG  - 1023-6
AB  - The adenomatous polyposis coli gene (APC) is mutated in most colon cancers. The 
      APC protein binds to the cellular adhesion molecule beta-catenin, which is a 
      mammalian homolog of ARMADILLO, a component of the WINGLESS signaling pathway in 
      Drosophila development. Here it is shown that when beta-catenin is present in 
      excess, APC binds to another component of the WINGLESS pathway, glycogen synthase 
      kinase 3beta (GSK3beta), a mammalian homolog of Drosophila ZESTE WHITE 3. APC was 
      a good substrate for GSK3 beta in vitro, and the phosphorylation sites were 
      mapped to the central region of APC. Binding of beta-catenin to this region was 
      dependent on phosphorylation by GSK3 beta.
FAU - Rubinfeld, B
AU  - Rubinfeld B
AD  - Onyx Pharmaceuticals, Richmond, CA 94806, USA.
FAU - Albert, I
AU  - Albert I
FAU - Porfiri, E
AU  - Porfiri E
FAU - Fiol, C
AU  - Fiol C
FAU - Munemitsu, S
AU  - Munemitsu S
FAU - Polakis, P
AU  - Polakis P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Adenomatous Polyposis Coli Protein)
RN  - 0 (CTNNB1 protein, human)
RN  - 0 (CTNNB1 protein, mouse)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (beta Catenin)
RN  - EC 2.7.11.- (Glycogen Synthase Kinases)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.26 (Glycogen Synthase Kinase 3)
SB  - IM
CIN - Science. 1996 May 17;272(5264):974-5. PMID: 8638142
MH  - Adenomatous Polyposis Coli Protein
MH  - Animals
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*metabolism
MH  - Cell Line
MH  - Cytoskeletal Proteins/*metabolism
MH  - Glycogen Synthase Kinase 3
MH  - Glycogen Synthase Kinases
MH  - Humans
MH  - Mice
MH  - Mutation
MH  - Phosphorylation
MH  - Protein Binding
MH  - *Trans-Activators
MH  - Tumor Cells, Cultured
MH  - beta Catenin
EDAT- 1996/05/17 00:00
MHDA- 1996/05/17 00:01
CRDT- 1996/05/17 00:00
PHST- 1996/05/17 00:00 [pubmed]
PHST- 1996/05/17 00:01 [medline]
PHST- 1996/05/17 00:00 [entrez]
AID - 10.1126/science.272.5264.1023 [doi]
PST - ppublish
SO  - Science. 1996 May 17;272(5264):1023-6. doi: 10.1126/science.272.5264.1023.