PMID- 8646781
OWN - NLM
STAT- MEDLINE
DCOM- 19960725
LR  - 20220225
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 85
IP  - 5
DP  - 1996 May 31
TI  - A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, 
      and female sterility in p27(Kip1)-deficient mice.
PG  - 733-44
AB  - Targeted disruption of the murine p27(Kip1) gene caused a gene dose-dependent 
      increase in animal size without other gross morphologic abnormalities. All 
      tissues were enlarged and contained more cells, although endocrine abnormalities 
      were not evident. Thymic hyperplasia was associated with increased T lymphocyte 
      proliferation, and T cells showed enhanced IL-2 responsiveness in vitro. Thus, 
      p27 deficiency may cause a cell-autonomous defect resulting in enhanced 
      proliferation in response to mitogens. In the spleen, the absence of p27 
      selectively enhanced proliferation of hematopoietic progenitor cells. p27 
      deletion, like deletion of the Rb gene, uniquely caused neoplastic growth of the 
      pituitary pars intermedia, suggesting that p27 and Rb function in the same 
      regulatory pathway. The absence of p27 also caused an ovulatory defect and female 
      sterility. Maturation of secondary ovarian follicles into corpora lutea, which 
      express high levels of p27, was markedly impaired.
FAU - Fero, M L
AU  - Fero ML
AD  - Department of Basic Sciences, Division of Public Health, Fred Hutchinson Cancer 
      Research Center, Seattle, Washington 98104, USA.
FAU - Rivkin, M
AU  - Rivkin M
FAU - Tasch, M
AU  - Tasch M
FAU - Porter, P
AU  - Porter P
FAU - Carow, C E
AU  - Carow CE
FAU - Firpo, E
AU  - Firpo E
FAU - Polyak, K
AU  - Polyak K
FAU - Tsai, L H
AU  - Tsai LH
FAU - Broudy, V
AU  - Broudy V
FAU - Perlmutter, R M
AU  - Perlmutter RM
FAU - Kaushansky, K
AU  - Kaushansky K
FAU - Roberts, J M
AU  - Roberts JM
LA  - eng
GR  - GM53049/GM/NIGMS NIH HHS/United States
GR  - R01 CA 31615/CA/NCI NIH HHS/United States
GR  - R01 DK 49855/DK/NIDDK NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Cdkn1b protein, mouse)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DNA Primers)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 147604-94-2 (Cyclin-Dependent Kinase Inhibitor p27)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinases)
SB  - IM
MH  - Adenoma/genetics/pathology
MH  - Animals
MH  - Base Sequence
MH  - *Cell Cycle Proteins
MH  - Cyclin-Dependent Kinase Inhibitor p27
MH  - Cyclin-Dependent Kinases/antagonists & inhibitors
MH  - DNA Primers/genetics
MH  - Enzyme Inhibitors/metabolism
MH  - Female
MH  - Gene Targeting
MH  - Gigantism/*genetics/pathology
MH  - Hyperplasia
MH  - Infertility, Female/*genetics/pathology
MH  - Lymphocyte Activation
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Microtubule-Associated Proteins/*deficiency/*genetics/physiology
MH  - Molecular Sequence Data
MH  - Pituitary Neoplasms/*genetics/pathology
MH  - Syndrome
MH  - T-Lymphocytes/immunology
MH  - Thymus Hyperplasia/genetics/immunology
MH  - *Tumor Suppressor Proteins
EDAT- 1996/05/31 00:00
MHDA- 1996/05/31 00:01
CRDT- 1996/05/31 00:00
PHST- 1996/05/31 00:00 [pubmed]
PHST- 1996/05/31 00:01 [medline]
PHST- 1996/05/31 00:00 [entrez]
AID - S0092-8674(00)81239-8 [pii]
AID - 10.1016/s0092-8674(00)81239-8 [doi]
PST - ppublish
SO  - Cell. 1996 May 31;85(5):733-44. doi: 10.1016/s0092-8674(00)81239-8.