PMID- 8658145
OWN - NLM
STAT- MEDLINE
DCOM- 19960801
LR  - 20220321
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 272
IP  - 5268
DP  - 1996 Jun 14
TI  - Human homolog of patched, a candidate gene for the basal cell nevus syndrome.
PG  - 1668-71
AB  - The basal cell nevus syndrome (BCNS) is characterized by developmental 
      abnormalities and by the postnatal occurrence of cancers, especially basal cell 
      carcinomas (BCCs), the most common human cancer. Heritable mutations in BCNS 
      patients and a somatic mutation in a sporadic BCC were identified in a human 
      homolog of the Drosophila patched (ptc) gene. The ptc gene encodes a 
      transmembrane protein that in Drosophila acts in opposition to the Hedgehog 
      signaling protein, controlling cell fates, patterning, and growth in numerous 
      tissues. The human PTC gene appears to be crucial for proper embryonic 
      development and for tumor suppression.
FAU - Johnson, R L
AU  - Johnson RL
AD  - Department of Developmental Biology, Howard Hughes Medical Institute, Stanford 
      University School of Medicine, California 94305-5427, USA.
FAU - Rothman, A L
AU  - Rothman AL
FAU - Xie, J
AU  - Xie J
FAU - Goodrich, L V
AU  - Goodrich LV
FAU - Bare, J W
AU  - Bare JW
FAU - Bonifas, J M
AU  - Bonifas JM
FAU - Quinn, A G
AU  - Quinn AG
FAU - Myers, R M
AU  - Myers RM
FAU - Cox, D R
AU  - Cox DR
FAU - Epstein, E H Jr
AU  - Epstein EH Jr
FAU - Scott, M P
AU  - Scott MP
LA  - eng
SI  - GENBANK/U59464
GR  - AR3995/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Insect Hormones)
RN  - 0 (Membrane Proteins)
RN  - 0 (PTCH1 protein, human)
RN  - 0 (Patched Receptors)
RN  - 0 (Patched-1 Receptor)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (ptc protein, Drosophila)
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Animals
MH  - Basal Cell Nevus Syndrome/*genetics
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA, Neoplasm
MH  - Drosophila
MH  - *Drosophila Proteins
MH  - Female
MH  - Frameshift Mutation
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - Insect Hormones/genetics
MH  - Male
MH  - Membrane Proteins/*genetics
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Patched Receptors
MH  - Patched-1 Receptor
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single-Stranded Conformational
MH  - Protein Conformation
MH  - Receptors, Cell Surface
EDAT- 1996/06/14 00:00
MHDA- 2001/03/28 10:01
CRDT- 1996/06/14 00:00
PHST- 1996/06/14 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1996/06/14 00:00 [entrez]
AID - 10.1126/science.272.5268.1668 [doi]
PST - ppublish
SO  - Science. 1996 Jun 14;272(5268):1668-71. doi: 10.1126/science.272.5268.1668.