PMID- 8658171
OWN - NLM
STAT- MEDLINE
DCOM- 19960801
LR  - 20240109
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 272
IP  - 5270
DP  - 1996 Jun 28
TI  - CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for 
      macrophage-tropic HIV-1.
PG  - 1955-8
AB  - Human immunodeficiency virus-type 1 (HIV-1) entry requires fusion cofactors on 
      the CD4+ target cell. Fusin, a heterotrimeric GTP-binding protein (G 
      protein)-coupled receptor, serves as a cofactor for T cell line-tropic isolates. 
      The chemokines RANTES, MIP-1alpha, and MIP-1beta, which suppress infection by 
      macrophage-tropic isolates, selectively inhibited cell fusion mediated by the 
      corresponding envelope glycoproteins (Envs). Recombinant CC CKR5, a G 
      protein-coupled receptor for these chemokines, rendered CD4-expressing nonhuman 
      cells fusion-competent preferentially with macrophage-tropic Envs. CC CKR5 
      messenger RNA was detected selectively in cell types susceptible to 
      macrophage-tropic isolates. CC CKR5 is thus a fusion cofactor for 
      macrophage-tropic HIV-1 strains.
FAU - Alkhatib, G
AU  - Alkhatib G
AD  - Laboratory of Viral Diseases, National Institute of Allergy and Infectious 
      Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland 20892, 
      USA.
FAU - Combadiere, C
AU  - Combadiere C
FAU - Broder, C C
AU  - Broder CC
FAU - Feng, Y
AU  - Feng Y
FAU - Kennedy, P E
AU  - Kennedy PE
FAU - Murphy, P M
AU  - Murphy PM
FAU - Berger, E A
AU  - Berger EA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (CD4 Antigens)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokines)
RN  - 0 (Gene Products, env)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (Monokines)
RN  - 0 (Receptors, CCR5)
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Receptors, HIV)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - 3T3 Cells
MH  - Animals
MH  - CD4 Antigens/physiology
MH  - Cell Fusion
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Chemokine CCL5/metabolism/pharmacology
MH  - Chemokines/*metabolism/pharmacology
MH  - Gene Products, env/physiology
MH  - Giant Cells/metabolism
MH  - HIV-1/pathogenicity/*physiology
MH  - HeLa Cells
MH  - Humans
MH  - Macrophage Inflammatory Proteins
MH  - Macrophages/*virology
MH  - Membrane Fusion
MH  - Mice
MH  - Monokines/metabolism/pharmacology
MH  - Receptors, CCR5
MH  - Receptors, Cytokine/*physiology
MH  - Receptors, HIV/*physiology
MH  - Recombinant Proteins/pharmacology
MH  - T-Lymphocytes/virology
MH  - Tumor Cells, Cultured
EDAT- 1996/06/28 00:00
MHDA- 1996/06/28 00:01
CRDT- 1996/06/28 00:00
PHST- 1996/06/28 00:00 [pubmed]
PHST- 1996/06/28 00:01 [medline]
PHST- 1996/06/28 00:00 [entrez]
AID - 10.1126/science.272.5270.1955 [doi]
PST - ppublish
SO  - Science. 1996 Jun 28;272(5270):1955-8. doi: 10.1126/science.272.5270.1955.