PMID- 8674417
OWN - NLM
STAT- MEDLINE
DCOM- 19960812
LR  - 20220215
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 122
IP  - 6
DP  - 1996 Jun
TI  - Distinct mitogenic and cell fate specification functions of wingless in different 
      regions of the wing.
PG  - 1781-9
AB  - Patterning and proliferation are coordinately controlled in the development of 
      Drosophila imaginal discs. Localized expression of decapentaplegic (dpp) at the 
      anterior-posterior and wingless (wg) at the dorsal-ventral compartment boundaries 
      controls growth of the wing with respect to the A/P and D/V axes. The 
      growth-promoting effects of these organizers are thought to be indirect, since 
      growth is dispersed throughout the disc, and is not localized near the sources of 
      wg or dpp. wg has also been implicated in proximal-distal patterning of the wing 
      hinge. In this report, we present evidence that wg is principally required for 
      local cell proliferation in the hinge. Loss of wg expression leads to a local 
      reduction in cell division, resulting in the deletion of a distinct set of wing 
      hinge structures. Ectopic activation of the wg pathway in cells of the wing hinge 
      leads to overproliferation without repatterning, indicating that wg acts as a 
      mitogen in this part of the disc. By contrast, overexpression of wg in the wing 
      blade leads to repatterning and only secondarily to proliferation. These results 
      suggest that the Wg signal elicits very different responses in different regions 
      of the wing imaginal disc.
FAU - Neumann, C J
AU  - Neumann CJ
AD  - European Molecular Biology Laboratory, Heidelberg, Germany.
FAU - Cohen, S M
AU  - Cohen SM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Drosophila Proteins)
RN  - 0 (Growth Substances)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Wnt1 Protein)
RN  - 0 (wg protein, Drosophila)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Cell Division
MH  - Drosophila
MH  - *Drosophila Proteins
MH  - Enhancer Elements, Genetic
MH  - Gene Expression Regulation, Developmental
MH  - Growth Substances/genetics/*physiology
MH  - Mutation
MH  - Phenotype
MH  - Proto-Oncogene Proteins/genetics/*physiology
MH  - Wings, Animal/embryology
MH  - Wnt1 Protein
EDAT- 1996/06/01 00:00
MHDA- 1996/06/01 00:01
CRDT- 1996/06/01 00:00
PHST- 1996/06/01 00:00 [pubmed]
PHST- 1996/06/01 00:01 [medline]
PHST- 1996/06/01 00:00 [entrez]
AID - 10.1242/dev.122.6.1781 [doi]
PST - ppublish
SO  - Development. 1996 Jun;122(6):1781-9. doi: 10.1242/dev.122.6.1781.