PMID- 8692268 OWN - NLM STAT- MEDLINE DCOM- 19960823 LR - 20240104 IS - 0028-0836 (Print) IS - 0028-0836 (Linking) VI - 381 IP - 6580 DP - 1996 May 23 TI - Specification of the wing by localized expression of wingless protein. PG - 316-8 AB - Limb development in Drosophila depends on subdivision of the limb primordia into functional units called compartments. Cell interactions across compartment boundaries establish pattern-organizing centres that control growth and specify cell fates along the anteroposterior (AP) and dorsoventral (DV) axes of the limbs. AP subdivision of the disc primordia is inherited from the embryonic ectoderm. DV subdivision of the wing disc occurs during the second larval instar through localized expression of the apterous protein (Apterous) in dorsal cells. A third major subdivision of the wing disc into wing and body-wall compartments also occurs in the second instar. Here we show that specification of the wing primordium in early second instar depends on activity of the AP patterning system but not the DV system. These results define two distinct roles for the wingless gene: a primary role in specifying the wing primordium, and a subsequent role mediating the patterning activities of the DV compartment boundary. FAU - Ng, M AU - Ng M AD - European Molecular Biology Laboratory, Heidelberg, Germany. FAU - Diaz-Benjumea, F J AU - Diaz-Benjumea FJ FAU - Vincent, J P AU - Vincent JP FAU - Wu, J AU - Wu J FAU - Cohen, S M AU - Cohen SM LA - eng PT - Journal Article PL - England TA - Nature JT - Nature JID - 0410462 RN - 0 (Drosophila Proteins) RN - 0 (Proto-Oncogene Proteins) RN - 0 (Wnt1 Protein) RN - 0 (wg protein, Drosophila) SB - IM MH - Animals MH - Drosophila/cytology/*embryology/genetics MH - *Drosophila Proteins MH - Morphogenesis/physiology MH - Mutation MH - Proto-Oncogene Proteins/genetics/*physiology MH - Wings, Animal/cytology/*embryology MH - Wnt1 Protein EDAT- 1996/05/23 00:00 MHDA- 1996/05/23 00:01 CRDT- 1996/05/23 00:00 PHST- 1996/05/23 00:00 [pubmed] PHST- 1996/05/23 00:01 [medline] PHST- 1996/05/23 00:00 [entrez] AID - 10.1038/381316a0 [doi] PST - ppublish SO - Nature. 1996 May 23;381(6580):316-8. doi: 10.1038/381316a0.