PMID- 8698237
OWN - NLM
STAT- MEDLINE
DCOM- 19960905
LR  - 20190524
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 10
IP  - 14
DP  - 1996 Jul 15
TI  - grim, a novel cell death gene in Drosophila.
PG  - 1773-82
AB  - A genomic interval at 75C1,2 is required for programmed cell death in Drosophila. 
      We identified a new activator of apoptosis, grim, which maps between two 
      previously identified cell death genes in this region reaper (rpr) and head 
      involution defective (hid). Expression of grim RNA coincided with the onset of 
      programmed cell death at all stages of embryonic development, whereas ectopic 
      induction of grim triggered extensive apoptosis in both transgenic animals and in 
      cell culture. Cell killing by grim was blocked by coexpression of p35, a viral 
      product that inactivates ICE-like proteases, and did not require the functions of 
      rpr or hid. The predicted grim protein shares an amino-terminal motif in common 
      with rpr. However, grim was sufficient to elicit apoptosis in at least one 
      context, where rpr was not. The grim gene product might thus function in a 
      parallel circuit of cell death signaling that ultimately activates a common set 
      of downstream apoptotic effectors.
FAU - Chen, P
AU  - Chen P
AD  - Department of Cell Biology and Neuroscience, University of Texas Southwestern 
      Medical Center, Dallas 75235-9039, USA.
FAU - Nordstrom, W
AU  - Nordstrom W
FAU - Gish, B
AU  - Gish B
FAU - Abrams, J M
AU  - Abrams JM
LA  - eng
SI  - GENBANK/U61976
GR  - AG12466/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (DNA, Complementary)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Peptides)
RN  - 0 (Viral Proteins)
RN  - 0 (grim protein, Drosophila)
RN  - 0 (inhibitor of apoptosis, Nucleopolyhedrovirus)
RN  - 0 (rpr protein, Drosophila)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Apoptosis/*genetics
MH  - Base Sequence
MH  - DNA, Complementary/genetics
MH  - Drosophila/cytology/embryology/*genetics
MH  - *Drosophila Proteins
MH  - Gene Expression Regulation, Developmental
MH  - *Genes, Insect
MH  - Inhibitor of Apoptosis Proteins
MH  - Models, Biological
MH  - Molecular Sequence Data
MH  - Neuropeptides/genetics
MH  - Peptides/genetics
MH  - RNA/genetics/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - Viral Proteins/genetics
EDAT- 1996/07/15 00:00
MHDA- 1996/07/15 00:01
CRDT- 1996/07/15 00:00
PHST- 1996/07/15 00:00 [pubmed]
PHST- 1996/07/15 00:01 [medline]
PHST- 1996/07/15 00:00 [entrez]
AID - 10.1101/gad.10.14.1773 [doi]
PST - ppublish
SO  - Genes Dev. 1996 Jul 15;10(14):1773-82. doi: 10.1101/gad.10.14.1773.