PMID- 8717036
OWN - NLM
STAT- MEDLINE
DCOM- 19961113
LR  - 20231120
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 382
IP  - 6588
DP  - 1996 Jul 18
TI  - A new member of the frizzled family from Drosophila functions as a Wingless 
      receptor.
PG  - 225-30
AB  - Receptors for Wingless and other signalling molecules of the Wnt gene family have 
      yet to be identified. We show here that cultured Drosophila cells transfected 
      with a novel member of the frizzled gene family in Drosophila, Dfz2, respond to 
      added Wingless protein by elevating the level of the Armadillo protein. Moreover, 
      Wingless binds to Drosophila or human cells expressing Dfz2. These data 
      demonstrate that Dfz2 functions as a Wingless receptor, and they imply, in 
      general, that Frizzled proteins are receptors for the Wnt signalling molecules.
FAU - Bhanot, P
AU  - Bhanot P
AD  - Department of Molecular Biology and Genetics, Johns Hopkins University School of 
      Medicine, Baltimore, Maryland 21205, USA.
FAU - Brink, M
AU  - Brink M
FAU - Samos, C H
AU  - Samos CH
FAU - Hsieh, J C
AU  - Hsieh JC
FAU - Wang, Y
AU  - Wang Y
FAU - Macke, J P
AU  - Macke JP
FAU - Andrew, D
AU  - Andrew D
FAU - Nathans, J
AU  - Nathans J
FAU - Nusse, R
AU  - Nusse R
LA  - eng
SI  - GENBANK/U65589
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (ARM protein, Drosophila)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Armadillo Domain Proteins)
RN  - 0 (Dishevelled Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Frizzled Receptors)
RN  - 0 (Phosphoproteins)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Receptors, Neurotransmitter)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Wnt1 Protein)
RN  - 0 (fz2 protein, Drosophila)
RN  - 0 (wg protein, Drosophila)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Armadillo Domain Proteins
MH  - Cell Line
MH  - Cloning, Molecular
MH  - Dishevelled Proteins
MH  - *Drosophila Proteins
MH  - Drosophila melanogaster/*genetics
MH  - Female
MH  - Frizzled Receptors
MH  - Gene Expression
MH  - Genes, Insect
MH  - Humans
MH  - Male
MH  - Molecular Sequence Data
MH  - *Phosphoproteins
MH  - Protein Biosynthesis
MH  - Proteins/metabolism
MH  - Proto-Oncogene Proteins/*metabolism
MH  - RNA/metabolism
MH  - Receptors, Cell Surface/genetics/*metabolism
MH  - Receptors, G-Protein-Coupled
MH  - *Receptors, Neurotransmitter
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - *Trans-Activators
MH  - Transcription Factors
MH  - Transfection
MH  - Wnt1 Protein
EDAT- 1996/07/18 00:00
MHDA- 1996/07/18 00:01
CRDT- 1996/07/18 00:00
PHST- 1996/07/18 00:00 [pubmed]
PHST- 1996/07/18 00:01 [medline]
PHST- 1996/07/18 00:00 [entrez]
AID - 10.1038/382225a0 [doi]
PST - ppublish
SO  - Nature. 1996 Jul 18;382(6588):225-30. doi: 10.1038/382225a0.