PMID- 8843599
OWN - NLM
STAT- MEDLINE
DCOM- 19961230
LR  - 20220321
IS  - 0166-2236 (Print)
IS  - 0166-2236 (Linking)
VI  - 19
IP  - 8
DP  - 1996 Aug
TI  - Microglia: a sensor for pathological events in the CNS.
PG  - 312-8
AB  - The most characteristic feature of microglial cells is their rapid activation in 
      response to even minor pathological changes in the CNS. Microglia activation is a 
      key factor in the defence of the neural parenchyma against infectious diseases, 
      inflammation, trauma, ischaemia, brain tumours and neurodegeneration. Microglia 
      activation occurs as a graded response in vivo. The transformation of microglia 
      into potentially cytotoxic cells is under strict control and occurs mainly in 
      response to neuronal or terminal degeneration, or both. Activated microglia are 
      mainly scavenger cells but also perform various other functions in tissue repair 
      and neural regeneration. They form a network of immune alert resident macrophages 
      with a capacity for immune surveillance and control. Activated microglia can 
      destroy invading micro-organisms, remove potentially deleterious debris, promote 
      tissue repair by secreting growth factors and thus facilitate the return to 
      tissue homeostasis. An understanding of intercellular signalling pathways for 
      microglia proliferation and activation could form a rational basis for targeted 
      intervention on glial reactions to injuries in the CNS.
FAU - Kreutzberg, G W
AU  - Kreutzberg GW
AD  - Dept of Neuromorphology, Max-Planck-Institute of Psychiatry, Martinsried near 
      Munich, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Trends Neurosci
JT  - Trends in neurosciences
JID - 7808616
SB  - IM
MH  - Animals
MH  - Central Nervous System/*injuries/pathology
MH  - Central Nervous System Diseases/*pathology
MH  - Humans
MH  - Microglia/*physiology
RF  - 75
EDAT- 1996/08/01 00:00
MHDA- 1996/08/01 00:01
CRDT- 1996/08/01 00:00
PHST- 1996/08/01 00:00 [pubmed]
PHST- 1996/08/01 00:01 [medline]
PHST- 1996/08/01 00:00 [entrez]
AID - 0166-2236(96)10049-7 [pii]
AID - 10.1016/0166-2236(96)10049-7 [doi]
PST - ppublish
SO  - Trends Neurosci. 1996 Aug;19(8):312-8. doi: 10.1016/0166-2236(96)10049-7.