PMID- 8893021
OWN - NLM
STAT- MEDLINE
DCOM- 19961216
LR  - 20240324
IS  - 0896-6273 (Print)
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Linking)
VI  - 17
IP  - 4
DP  - 1996 Oct
TI  - Regulation of synapse structure and function by the Drosophila tumor suppressor 
      gene dlg.
PG  - 627-40
AB  - Mutations of the tumor suppressor gene discs-large (dlg) lead to postsynaptic 
      structural defects. Here, we report that mutations in dlg also result in larger 
      synaptic currents at fly neuromuscular junctions. By selectively targeting DLG 
      protein to either muscles or motorneurons using Gal-4 enhancer trap lines, we 
      were able to rescue substantially the reduced postsynaptic structure in mutants. 
      Rescue of the physiological defect was accomplished by presynaptic, but not 
      postsynaptic targeting, consistent with our finding that miniature excitatory 
      junctional currents were not changed in dlg mutants. These results suggest that 
      DLG functions in the regulation of neurotransmitter release and postsynaptic 
      structure. We propose that DLG is an integral part of a mechanism by which 
      changes in both neurotransmitter release and synapse structure are accomplished 
      during development and plasticity.
FAU - Budnik, V
AU  - Budnik V
AD  - Department of Biology, University of Massachusetts, Amherst 01003, USA.
FAU - Koh, Y H
AU  - Koh YH
FAU - Guan, B
AU  - Guan B
FAU - Hartmann, B
AU  - Hartmann B
FAU - Hough, C
AU  - Hough C
FAU - Woods, D
AU  - Woods D
FAU - Gorczyca, M
AU  - Gorczyca M
LA  - eng
GR  - R01 NS030072/NS/NINDS NIH HHS/United States
GR  - R21 NS070032/NS/NINDS NIH HHS/United States
GR  - K04 NS01786/NS/NINDS NIH HHS/United States
GR  - R01 NS70032/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Drosophila Proteins)
RN  - 0 (Insect Hormones)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 143513-41-1 (dlg1 protein, Drosophila)
SB  - IM
MH  - Animals
MH  - Axons
MH  - Drosophila/genetics/*physiology
MH  - *Drosophila Proteins
MH  - Evoked Potentials
MH  - *Gene Expression Regulation, Developmental
MH  - Genes, Insect
MH  - *Genes, Tumor Suppressor
MH  - Insect Hormones/biosynthesis/*genetics
MH  - Microscopy, Electron
MH  - Motor Neurons/physiology/ultrastructure
MH  - Muscles/innervation
MH  - Mutagenesis
MH  - Neuromuscular Junction/*physiology/ultrastructure
MH  - Synapses/*physiology/*ultrastructure
MH  - Synaptic Transmission
MH  - *Tumor Suppressor Proteins
PMC - PMC4661176
MID - NIHMS384199
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
PMCR- 2015/11/27
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
PHST- 2015/11/27 00:00 [pmc-release]
AID - S0896-6273(00)80196-8 [pii]
AID - 10.1016/s0896-6273(00)80196-8 [doi]
PST - ppublish
SO  - Neuron. 1996 Oct;17(4):627-40. doi: 10.1016/s0896-6273(00)80196-8.