PMID- 8917507
OWN - NLM
STAT- MEDLINE
DCOM- 19961230
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 93
IP  - 23
DP  - 1996 Nov 12
TI  - Transcriptional repression by YY1 is mediated by interaction with a mammalian 
      homolog of the yeast global regulator RPD3.
PG  - 12845-50
AB  - YY1 is a mammalian zinc-finger transcription factor with unusual structural and 
      functional features. It has been implicated as a positive and a negative 
      regulatory factor that binds to the CCATNTT consensus DNA element located in 
      promoters of many cellular and viral genes. A mammalian cDNA that encodes a 
      YY1-binding protein and possesses sequence homology with the yeast 
      transcriptional factor RPD3 has been identified. A Gal4 DNA binding 
      domain-mammalian RPD3 fusion protein strongly represses transcription from a 
      promoter containing Gal4 binding sites. Association between YY1 and mammalian 
      RPD3 requires a glycine-rich region on YY1. Mutations in this region abolish the 
      interaction with mammalian RPD3 and eliminate transcriptional repression by YY1. 
      These data suggest that YY1 negatively regulates transcription by tethering RPD3 
      to DNA as a cofactor and that this transcriptional mechanism is highly conserved 
      from yeast to human.
FAU - Yang, W M
AU  - Yang WM
AD  - Moffitt Cancer Center and Research Institute, University of South Florida, Tampa 
      33612, USA.
FAU - Inouye, C
AU  - Inouye C
FAU - Zeng, Y
AU  - Zeng Y
FAU - Bearss, D
AU  - Bearss D
FAU - Seto, E
AU  - Seto E
LA  - eng
SI  - GENBANK/U31758
SI  - GENBANK/U31814
SI  - GENBANK/X78454
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Erythroid-Specific DNA-Binding Factors)
RN  - 0 (Fungal Proteins)
RN  - 0 (GAL4 protein, S cerevisiae)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (YY1 Transcription Factor)
RN  - 0 (YY1 protein, human)
RN  - 0 (Yy1 protein, mouse)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 3.5.1.- (RPD3 protein, S cerevisiae)
RN  - EC 3.5.1.98 (Histone Deacetylases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - DNA-Binding Proteins/biosynthesis/*metabolism
MH  - Erythroid-Specific DNA-Binding Factors
MH  - Fungal Proteins/biosynthesis/*chemistry/*metabolism
MH  - Glutathione Transferase/biosynthesis
MH  - Histone Deacetylases
MH  - Humans
MH  - Mammals
MH  - Mice
MH  - Molecular Sequence Data
MH  - Promoter Regions, Genetic
MH  - Recombinant Fusion Proteins/biosynthesis/chemistry/metabolism
MH  - Recombinant Proteins/biosynthesis/metabolism
MH  - Saccharomyces cerevisiae/*metabolism
MH  - *Saccharomyces cerevisiae Proteins
MH  - Sequence Homology, Amino Acid
MH  - Transcription Factors/biosynthesis/*chemistry/*metabolism
MH  - *Transcription, Genetic
MH  - YY1 Transcription Factor
MH  - Zinc Fingers
PMC - PMC24008
EDAT- 1996/11/12 00:00
MHDA- 1996/11/12 00:01
PMCR- 1997/05/12
CRDT- 1996/11/12 00:00
PHST- 1996/11/12 00:00 [pubmed]
PHST- 1996/11/12 00:01 [medline]
PHST- 1996/11/12 00:00 [entrez]
PHST- 1997/05/12 00:00 [pmc-release]
AID - 0879 [pii]
AID - 10.1073/pnas.93.23.12845 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12845-50. doi: 
      10.1073/pnas.93.23.12845.