PMID- 8945469 OWN - NLM STAT- MEDLINE DCOM- 19970106 LR - 20211018 IS - 0028-0836 (Print) IS - 0028-0836 (Linking) VI - 384 IP - 6608 DP - 1996 Dec 5 TI - Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. PG - 432-8 AB - The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec61 complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum. FAU - Wiertz, E J AU - Wiertz EJ AD - Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA. FAU - Tortorella, D AU - Tortorella D FAU - Bogyo, M AU - Bogyo M FAU - Yu, J AU - Yu J FAU - Mothes, W AU - Mothes W FAU - Jones, T R AU - Jones TR FAU - Rapoport, T A AU - Rapoport TA FAU - Ploegh, H L AU - Ploegh HL LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - England TA - Nature JT - Nature JID - 0410462 RN - 0 (Histocompatibility Antigens Class I) RN - 0 (Membrane Proteins) RN - 0 (Multienzyme Complexes) RN - 0 (SEC Translocation Channels) RN - 0 (Viral Proteins) RN - 8L70Q75FXE (Adenosine Triphosphate) RN - EC 3.4.22.- (Cysteine Endopeptidases) RN - EC 3.4.25.1 (Proteasome Endopeptidase Complex) SB - IM CIN - Nature. 1996 Dec 5;384(6608):405-6. PMID: 8945460 MH - Adenosine Triphosphate/metabolism MH - Biological Transport, Active MH - Cell Line MH - Cysteine Endopeptidases/*metabolism MH - Cytomegalovirus/immunology MH - Cytosol/metabolism MH - Endoplasmic Reticulum/*metabolism MH - Glycosylation MH - Histocompatibility Antigens Class I/metabolism MH - Humans MH - Membrane Proteins/*metabolism MH - Multienzyme Complexes/*metabolism MH - Proteasome Endopeptidase Complex MH - Protein Folding MH - SEC Translocation Channels MH - Viral Proteins/immunology EDAT- 1996/12/05 00:00 MHDA- 1996/12/05 00:01 CRDT- 1996/12/05 00:00 PHST- 1996/12/05 00:00 [pubmed] PHST- 1996/12/05 00:01 [medline] PHST- 1996/12/05 00:00 [entrez] AID - 10.1038/384432a0 [doi] PST - ppublish SO - Nature. 1996 Dec 5;384(6608):432-8. doi: 10.1038/384432a0.