PMID- 8946916
OWN - NLM
STAT- MEDLINE
DCOM- 19970114
LR  - 20190606
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 10
IP  - 21
DP  - 1996 Nov 1
TI  - The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not 
      for DJun-dependent cell fate specification in the eye.
PG  - 2759-68
AB  - We cloned and characterized the Drosophila homolog of mammalian Jun-N-terminal 
      kinases (DJNK). We show that DJNK is encoded by basket (bsk). Like hemipterous 
      (hep), which encodes the Drosophila JNK kinase, bsk is required in the embryo for 
      dorsal closure, a process involving coordinate cell shape changes of ectodermal 
      cells. Dorsal closure can also be blocked by dominant negative Drosophila cdc42, 
      which has been shown to act upstream of JNKK in vertebrates. Therefore it appears 
      that the JNK pathway is conserved and that it is involved in controlling cell 
      morphogenesis in Drosophila. Although DJNK efficiently phosphorylates DJun in 
      vitro, bsk function is not required for the specification of cell fate in the 
      developing eye, a process that requires MAP kinase and DJun function.
FAU - Riesgo-Escovar, J R
AU  - Riesgo-Escovar JR
AD  - Zoologisches Institut, Universitat Zurich, Switzerland.
FAU - Jenni, M
AU  - Jenni M
FAU - Fritz, A
AU  - Fritz A
FAU - Hafen, E
AU  - Hafen E
LA  - eng
SI  - GENBANK/U73196
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Drosophila Proteins)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.12.2 (Hep protein, Drosophila)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Lineage
MH  - Drosophila/embryology/*enzymology
MH  - *Drosophila Proteins
MH  - Eye/embryology/*metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Gene Expression Regulation, Enzymologic
MH  - Genes, Dominant
MH  - Mitogen-Activated Protein Kinase Kinases/genetics/*metabolism
MH  - Molecular Sequence Data
MH  - Morphogenesis
MH  - Mutation
MH  - Phenotype
MH  - Protein Kinases/genetics/*metabolism
MH  - Sequence Homology, Amino Acid
EDAT- 1996/11/01 00:00
MHDA- 2000/06/01 09:00
CRDT- 1996/11/01 00:00
PHST- 1996/11/01 00:00 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1996/11/01 00:00 [entrez]
AID - 10.1101/gad.10.21.2759 [doi]
PST - ppublish
SO  - Genes Dev. 1996 Nov 1;10(21):2759-68. doi: 10.1101/gad.10.21.2759.