PMID- 8951794
OWN - NLM
STAT- MEDLINE
DCOM- 19970513
LR  - 20190909
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 59
IP  - 2
DP  - 1996 Oct
TI  - Zebrafish Hoxa and Evx-2 genes: cloning, developmental expression and 
      implications for the functional evolution of posterior Hox genes.
PG  - 165-75
AB  - Vertebrate Hox genes are required for the establishment of regional identities 
      along body axes. This gene family is strongly conserved among vertebrates, even 
      in bony fish which display less complex ranges of axial morphologies. We have 
      analysed the structural organization and expression of Abd-B related zebrafish 
      HoxA cluster genes (Hoxa-9, Hoxa-10, Hoxa-11 and Hoxa-13) as well as of Evx-2, a 
      gene closely linked to the HoxD complex. We show that the genomic organization of 
      Hoxa genes in fish resembles that of tetrapods albeit intergenic distances are 
      shorter. During development of the fish trunk, Hoxa genes are coordinately 
      expressed, whereas in pectoral fins, they display transcript domains similar to 
      those observed in developing tetrapod limbs. Likewise, the Evx-2 gene seems to 
      respond to both Hox- and Evx-types of regulation. During fin development, this 
      latter gene is expressed as the neighbouring Hox genes, in contrast to its 
      expression in the central nervous system which does not comply with colinearity 
      and extends up to anterior parts of the brain. These results are discussed in the 
      context of the functional evolution of Hoxa versus Hoxd genes and their different 
      roles in building up paired appendages.
FAU - Sordino, P
AU  - Sordino P
AD  - Department of Zoology and Animal Biology, University of Geneva, Switzerland.
FAU - Duboule, D
AU  - Duboule D
FAU - Kondo, T
AU  - Kondo T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Evx2 protein, zebrafish)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (RNA Probes)
RN  - 0 (Zebrafish Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/*genetics
MH  - *Genes, Homeobox
MH  - *Homeodomain Proteins
MH  - In Situ Hybridization
MH  - Molecular Sequence Data
MH  - RNA Probes/metabolism
MH  - Zebrafish/*genetics
MH  - *Zebrafish Proteins
EDAT- 1996/10/01 00:00
MHDA- 1996/10/01 00:01
CRDT- 1996/10/01 00:00
PHST- 1996/10/01 00:00 [pubmed]
PHST- 1996/10/01 00:01 [medline]
PHST- 1996/10/01 00:00 [entrez]
AID - 0925477396005874 [pii]
AID - 10.1016/0925-4773(96)00587-4 [doi]
PST - ppublish
SO  - Mech Dev. 1996 Oct;59(2):165-75. doi: 10.1016/0925-4773(96)00587-4.