PMID- 8971012
OWN - NLM
STAT- MEDLINE
DCOM- 19970123
LR  - 20240109
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 70
IP  - 12
DP  - 1996 Dec
TI  - Analysis of the complete DNA sequence of murine cytomegalovirus.
PG  - 8833-49
AB  - The complete DNA sequence of the Smith strain of murine cytomegalovirus (MCMV) 
      was determined from virion DNA by using a whole-genome shotgun approach. The 
      genome has an overall G+C content of 58.7%, consists of 230,278 bp, and is 
      arranged as a single unique sequence with short (31-bp) terminal direct repeats 
      and several short internal repeats. Significant similarity to the genome of the 
      sequenced human cytomegalovirus (HCMV) strain AD169 is evident, particularly for 
      78 open reading frames encoded by the central part of the genome. There is a very 
      similar distribution of G+C content across the two genomes. Sequences toward the 
      ends of the MCMV genome encode tandem arrays of homologous glycoproteins (gps) 
      arranged as two gene families. The left end encodes 15 gps that represent one 
      family, and the right end encodes a different family of 11 gps. A homolog (m144) 
      of cellular major histocompatibility complex (MHC) class I genes is located at 
      the end of the genome opposite the HCMV MHC class I homolog (UL18). G 
      protein-coupled receptor (GCR) homologs (M33 and M78) occur in positions 
      congruent with two (UL33 and UL78) of the four putative HCMV GCR homologs. 
      Counterparts of all of the known enzyme homologs in HCMV are present in the MCMV 
      genome, including the phosphotransferase gene (M97), whose product phosphorylates 
      ganciclovir in HCMV-infected cells, and the assembly protein (M80).
FAU - Rawlinson, W D
AU  - Rawlinson WD
AD  - Laboratory of Molecular Biology, Cambridge, United Kingdom. 
      WDR@westmed.wh.su.edu.au
FAU - Farrell, H E
AU  - Farrell HE
FAU - Barrell, B G
AU  - Barrell BG
LA  - eng
SI  - GENBANK/U68299
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (DNA, Viral)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - *DNA, Viral
MH  - *Genome, Viral
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Muromegalovirus/*genetics
MH  - Open Reading Frames
MH  - Sequence Homology, Nucleic Acid
MH  - Viral Proteins/genetics
PMC - PMC190980
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
PMCR- 1996/12/01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
PHST- 1996/12/01 00:00 [pmc-release]
AID - 10.1128/JVI.70.12.8833-8849.1996 [doi]
PST - ppublish
SO  - J Virol. 1996 Dec;70(12):8833-49. doi: 10.1128/JVI.70.12.8833-8849.1996.