PMID- 8978608
OWN - NLM
STAT- MEDLINE
DCOM- 19970128
LR  - 20220409
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 87
IP  - 6
DP  - 1996 Dec 13
TI  - A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid 
      organs and specific anatomic compartments of the spleen.
PG  - 1037-47
AB  - We describe the phenotype of gene-targeted mice lacking the putative chemokine 
      receptor BLR1. In normal mice, this receptor is expressed on mature B cells and a 
      subpopulation of T helper cells. Blr1 mutant mice lack inguinal lymph nodes and 
      possess no or only a few phenotypically abnormal Peyer's patches. The migration 
      of lymphocytes into splenic follicles is severely impaired, resulting in 
      morphologically altered primary lymphoid follicles. Furthermore, activated B 
      cells fail to migrate from the T cell-rich zone into B cell follicles of the 
      spleen, and despite high numbers of germinal center founder cells, no functional 
      germinal centers develop in this organ. Our results identify the putative 
      chemokine receptor BLR1 as the first G protein-coupled receptor involved in B 
      cell migration and localization of these cells within specific anatomic 
      compartments.
FAU - Forster, R
AU  - Forster R
AD  - Max-Delbruck-Center for Molecular Medicine, Berlin-Buch, Germany.
FAU - Mattis, A E
AU  - Mattis AE
FAU - Kremmer, E
AU  - Kremmer E
FAU - Wolf, E
AU  - Wolf E
FAU - Brem, G
AU  - Brem G
FAU - Lipp, M
AU  - Lipp M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (CXCR5 protein, mouse)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Receptors, CXCR5)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Receptors, Neuropeptide)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/chemistry/*cytology/physiology
MH  - Cell Movement/*physiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Flow Cytometry
MH  - GTP-Binding Proteins/*genetics
MH  - Gene Expression/physiology
MH  - Immunoglobulin M/analysis
MH  - Immunohistochemistry
MH  - Lymph Nodes/abnormalities/cytology
MH  - Lymphocyte Count
MH  - Mice
MH  - Mice, Knockout
MH  - Mutagenesis/physiology
MH  - Peyer's Patches/abnormalities/cytology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, CXCR5
MH  - Receptors, Chemokine
MH  - Receptors, Cytokine/*genetics
MH  - Receptors, Neuropeptide/*genetics
MH  - Spleen/abnormalities/*cytology/ultrastructure
EDAT- 1996/12/13 00:00
MHDA- 1996/12/13 00:01
CRDT- 1996/12/13 00:00
PHST- 1996/12/13 00:00 [pubmed]
PHST- 1996/12/13 00:01 [medline]
PHST- 1996/12/13 00:00 [entrez]
AID - S0092-8674(00)81798-5 [pii]
AID - 10.1016/s0092-8674(00)81798-5 [doi]
PST - ppublish
SO  - Cell. 1996 Dec 13;87(6):1037-47. doi: 10.1016/s0092-8674(00)81798-5.