PMID- 8978613
OWN - NLM
STAT- MEDLINE
DCOM- 19970128
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 87
IP  - 6
DP  - 1996 Dec 13
TI  - branchless encodes a Drosophila FGF homolog that controls tracheal cell migration 
      and the pattern of branching.
PG  - 1091-101
AB  - The molecular basis for patterning of complex organ structures like the lung and 
      insect tracheal system is unknown. Here, we describe the Drosophila gene 
      branchless (bnl) and demonstrate that it is a key determinant of the tracheal 
      branching pattern. bnl is required for tracheal branching and is expressed 
      dynamically in clusters of cells surrounding the developing tracheal system at 
      each position where a new branch will form and grow out. Localized misexpression 
      of bnl can direct branch formation and outgrowth to new positions. Generalized 
      misexpression activates later programs of tracheal gene expression and branching, 
      resulting in massive networks of branches. bnl encodes a homolog of mammalian 
      fibroblast growth factors (FGFs) and appears to function as a ligand for the 
      breathless receptor tyrosine kinase, an FGF receptor homolog expressed on 
      developing tracheal cells. The results suggest that this FGF pathway specifies 
      the tracheal branching pattern by guiding tracheal cell migration during primary 
      branch formation and then activating later programs of finer branching at the 
      ends of growing primary branches.
FAU - Sutherland, D
AU  - Sutherland D
AD  - Department of Biochemistry, Beckman Center, Stanford University School of 
      Medicine, California 94305-5307, USA.
FAU - Samakovlis, C
AU  - Samakovlis C
FAU - Krasnow, M A
AU  - Krasnow MA
LA  - eng
SI  - GENBANK/U82273
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (DNA, Complementary)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Receptors, Fibroblast Growth Factor)
RN  - 0 (bnl protein, Drosophila)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cell Movement/physiology
MH  - DNA, Complementary/genetics
MH  - Drosophila/*genetics
MH  - *Drosophila Proteins
MH  - Fibroblast Growth Factors/*genetics
MH  - Gene Expression Regulation, Developmental/physiology
MH  - Genes, Insect/physiology
MH  - Insect Proteins/*genetics
MH  - Larva/genetics
MH  - Molecular Sequence Data
MH  - Phenotype
MH  - Receptors, Fibroblast Growth Factor/physiology
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction/physiology
MH  - Trachea/cytology/embryology
EDAT- 1996/12/13 00:00
MHDA- 1996/12/13 00:01
CRDT- 1996/12/13 00:00
PHST- 1996/12/13 00:00 [pubmed]
PHST- 1996/12/13 00:01 [medline]
PHST- 1996/12/13 00:00 [entrez]
AID - S0092-8674(00)81803-6 [pii]
AID - 10.1016/s0092-8674(00)81803-6 [doi]
PST - ppublish
SO  - Cell. 1996 Dec 13;87(6):1091-101. doi: 10.1016/s0092-8674(00)81803-6.