PMID- 8980224
OWN - NLM
STAT- MEDLINE
DCOM- 19970203
LR  - 20220321
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 87
IP  - 7
DP  - 1996 Dec 27
TI  - Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during 
      embryonic angiogenesis.
PG  - 1171-80
AB  - Vascular endothelial growth factor (VEGF), which acts via members of a family of 
      endothelial-specific receptor tyrosine kinases, is the only factor that has been 
      shown definitively to play a role in the formation of the embryonic vasculature. 
      Only one other family of receptor tyrosine kinases, comprising TIE1 and TIE2, is 
      largely endothelial cell specific. We have recently cloned a ligand for TIE2, 
      termed Angiopoietin-1. Here we show that mice engineered to lack Angiopoietin-1 
      display angiogenic deficits reminiscent of those previously seen in mice lacking 
      TIE2, demonstrating that Angiopoietin-1 is a primary physiologic ligand for TIE2 
      and that it has critical in vivo angiogenic actions that are distinct from VEGF 
      and that are not reflected in the classic in vitro assays used to characterize 
      VEGF. Angiopoietin-1 seems to play a crucial role in mediating reciprocal 
      interactions between the endothelium and surrounding matrix and mesenchyme.
FAU - Suri, C
AU  - Suri C
AD  - Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591, USA.
FAU - Jones, P F
AU  - Jones PF
FAU - Patan, S
AU  - Patan S
FAU - Bartunkova, S
AU  - Bartunkova S
FAU - Maisonpierre, P C
AU  - Maisonpierre PC
FAU - Davis, S
AU  - Davis S
FAU - Sato, T N
AU  - Sato TN
FAU - Yancopoulos, G D
AU  - Yancopoulos GD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Angiopoietin-1)
RN  - 0 (Angpt1 protein, mouse)
RN  - 0 (Endothelial Growth Factors)
RN  - 0 (Glycoproteins)
RN  - 0 (Ligands)
RN  - 0 (Lymphokines)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factors)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, TIE-2)
SB  - IM
CIN - Cell. 1996 Dec 27;87(7):1153-5. PMID: 8980221
MH  - Angiopoietin-1
MH  - Animals
MH  - Blood Vessels/*embryology
MH  - Endocardium/embryology
MH  - Endothelial Growth Factors/physiology
MH  - Endothelium, Vascular/cytology/*embryology
MH  - Gene Expression Regulation, Developmental
MH  - Genes, Lethal
MH  - Gestational Age
MH  - Glycoproteins/*physiology
MH  - Heart/embryology
MH  - Ligands
MH  - Lymphokines/physiology
MH  - Membrane Glycoproteins/*physiology
MH  - Mice
MH  - Mice, Knockout
MH  - *Neovascularization, Physiologic
MH  - Protein-Tyrosine Kinases/*physiology
MH  - Proteins/*physiology
MH  - RNA, Messenger/genetics
MH  - Receptor, TIE-2
MH  - Vascular Endothelial Growth Factor A
MH  - Vascular Endothelial Growth Factors
EDAT- 1996/12/27 00:00
MHDA- 1996/12/27 00:01
CRDT- 1996/12/27 00:00
PHST- 1996/12/27 00:00 [pubmed]
PHST- 1996/12/27 00:01 [medline]
PHST- 1996/12/27 00:00 [entrez]
AID - S0092-8674(00)81813-9 [pii]
AID - 10.1016/s0092-8674(00)81813-9 [doi]
PST - ppublish
SO  - Cell. 1996 Dec 27;87(7):1171-80. doi: 10.1016/s0092-8674(00)81813-9.