PMID- 8980230
OWN - NLM
STAT- MEDLINE
DCOM- 19970203
LR  - 20211203
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 87
IP  - 7
DP  - 1996 Dec 27
TI  - A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from 
      the cell cycle during Drosophila embryogenesis.
PG  - 1237-47
AB  - In a screen for genes that interact with the Rap1 GTPase, we have identified a 
      Drosophila gene, dacapo (dap), which is a member of the p21/p27 family of cdk 
      inhibitors. Unlike mammalian cdk inhibitors studied to date, dap is essential for 
      normal embryonic development. Dacapo inhibits cyclin-cdk activity in vitro. 
      Overexpressing dap during eye development interferes with cell cycle progression 
      and interacts genetically with the retinoblastoma homolog (Rbf) and cyclin E. dap 
      expression in embryos parallels the exit of cells from the cell cycle. dap mutant 
      embryos delay the normal cell cycle exit during development; many cells complete 
      an additional cycle and subsequently become quiescent. Thus, dap functions during 
      embryogenesis to achieve a precisely timed exit from the cell cycle.
FAU - de Nooij, J C
AU  - de Nooij JC
AD  - Massachusetts General Hospital Cancer Center, Charlestown 02129, USA.
FAU - Letendre, M A
AU  - Letendre MA
FAU - Hariharan, I K
AU  - Hariharan IK
LA  - eng
SI  - GENBANK/U77937
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Cyclins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Growth Inhibitors)
RN  - 0 (Insect Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 0 (RNA, Messenger)
RN  - 0 (dap protein, Drosophila)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.- (histone H1 kinase)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.22 (CDC2-CDC28 Kinases)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinase 2)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinases)
RN  - EC 2.7.11.22 (cdk2 protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *CDC2-CDC28 Kinases
MH  - *Cell Cycle
MH  - Cloning, Molecular
MH  - Cyclin-Dependent Kinase 2
MH  - Cyclin-Dependent Kinases/*antagonists & inhibitors
MH  - Cyclins/*antagonists & inhibitors
MH  - *Drosophila Proteins
MH  - Drosophila melanogaster/*embryology/enzymology
MH  - Enzyme Inhibitors
MH  - Epidermal Cells
MH  - Eye/embryology
MH  - Gene Expression Regulation, Developmental
MH  - Genes, Insect
MH  - Genes, Lethal
MH  - *Growth Inhibitors
MH  - Insect Proteins/*physiology
MH  - Molecular Sequence Data
MH  - Mutagenesis, Insertional
MH  - Nuclear Proteins/*physiology
MH  - Protein Kinase Inhibitors
MH  - *Protein Kinases
MH  - Protein Serine-Threonine Kinases/*antagonists & inhibitors
MH  - RNA, Messenger/genetics
MH  - Sequence Alignment
EDAT- 1996/12/27 00:00
MHDA- 1996/12/27 00:01
CRDT- 1996/12/27 00:00
PHST- 1996/12/27 00:00 [pubmed]
PHST- 1996/12/27 00:01 [medline]
PHST- 1996/12/27 00:00 [entrez]
AID - S0092-8674(00)81819-X [pii]
AID - 10.1016/s0092-8674(00)81819-x [doi]
PST - ppublish
SO  - Cell. 1996 Dec 27;87(7):1237-47. doi: 10.1016/s0092-8674(00)81819-x.