PMID- 8985012 OWN - NLM STAT- MEDLINE DCOM- 19970123 LR - 20190618 IS - 0036-8075 (Print) IS - 0036-8075 (Linking) VI - 275 IP - 5297 DP - 1997 Jan 10 TI - Regulation of cell cycle synchronization by decapentaplegic during Drosophila eye development. PG - 203-6 AB - In the developing Drosophila eye, differentiation is coordinated with synchronized progression through the cell cycle. Signaling mediated by the transforming growth factor-beta-related gene decapentaplegic (dpp) was required for the synchronization of the cell cycle but not for cell fate specification. DPP may affect cell cycle synchronization by promoting cell cycle progression through the G2-M phases. This synchronization is critical for the precise assembly of the eye. FAU - Penton, A AU - Penton A AD - McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Medical School, Madison, WI 53706, USA. FAU - Selleck, S B AU - Selleck SB FAU - Hoffmann, F M AU - Hoffmann FM LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Science JT - Science (New York, N.Y.) JID - 0404511 RN - 0 (Cyclins) RN - 0 (Drosophila Proteins) RN - 0 (Insect Proteins) RN - 0 (Membrane Glycoproteins) RN - 0 (Proteoglycans) RN - 0 (dally protein, Drosophila) RN - 0 (dpp protein, Drosophila) SB - IM MH - Animals MH - Body Patterning MH - *Cell Cycle MH - Cell Differentiation MH - Cell Nucleus/ultrastructure MH - Cyclins/metabolism MH - Drosophila/*genetics/physiology MH - *Drosophila Proteins MH - Eye/cytology MH - Female MH - G1 Phase MH - G2 Phase MH - *Genes, Insect MH - Insect Proteins/*genetics/physiology MH - Male MH - Membrane Glycoproteins/genetics/physiology MH - Mitosis MH - Mutation MH - Photoreceptor Cells, Invertebrate/*cytology MH - Proteoglycans/genetics/physiology MH - Signal Transduction EDAT- 1997/01/10 00:00 MHDA- 1997/01/10 00:01 CRDT- 1997/01/10 00:00 PHST- 1997/01/10 00:00 [pubmed] PHST- 1997/01/10 00:01 [medline] PHST- 1997/01/10 00:00 [entrez] AID - 10.1126/science.275.5297.203 [doi] PST - ppublish SO - Science. 1997 Jan 10;275(5297):203-6. doi: 10.1126/science.275.5297.203.