PMID- 9014863
OWN - NLM
STAT- MEDLINE
DCOM- 19970220
LR  - 20061115
IS  - 0022-3417 (Print)
IS  - 0022-3417 (Linking)
VI  - 180
IP  - 4
DP  - 1996 Dec
TI  - Differential growth of N- and S-type human neuroblastoma cells xenografted into 
      scid mice. correlation with apoptosis.
PG  - 415-22
AB  - This study concerns the role of apoptosis in the growth of human neuroblastomas 
      transplanted into immunodeficient SCID mice. Human neuroblastoma cell lines may 
      consist of one or more distinct phenotypes including the neural 'N-type' and flat 
      substrate-adherent 'S-type'. A differential phenotype-specific proliferation was 
      apparent among S- and N-type cell clones transplanted into SCID mice when 
      compared with the wild-type SK-N-BE(2) cell line. This differential growth 
      capacity of the tumours was correlated with spontaneous apoptosis. Another 
      SK-N-BE(2)-derived cell line (TGA), displaying high levels of apoptosis upon 
      stable transfection with the full length 'tissue' transglutaminase (tTG) cDNA, 
      was unable to induce tumour development when xenografted into SCID mice. To 
      support these observations, the expression of apoptosis-related genes (i.e., 
      bcl-2, p53, and tTG) in the various neuroblastomas was also investigated.
FAU - Piacentini, M
AU  - Piacentini M
AD  - Department of Biology, University of Rome Tor Vergata, Italy.
FAU - Piredda, L
AU  - Piredda L
FAU - Starace, D T
AU  - Starace DT
FAU - Annicchiarico-Petruzzelli, M
AU  - Annicchiarico-Petruzzelli M
FAU - Mattei, M
AU  - Mattei M
FAU - Oliverio, S
AU  - Oliverio S
FAU - Farrace, M G
AU  - Farrace MG
FAU - Melino, G
AU  - Melino G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - EC 2.3.2.13 (Transglutaminases)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Cell Division
MH  - Gene Expression
MH  - Humans
MH  - Mice
MH  - Mice, SCID
MH  - Mitotic Index
MH  - Neoplasm Transplantation
MH  - Neuroblastoma/metabolism/*pathology
MH  - Proto-Oncogene Proteins c-bcl-2/metabolism
MH  - Transglutaminases/metabolism
MH  - Transplantation, Heterologous
MH  - Tumor Cells, Cultured
MH  - Tumor Suppressor Protein p53/metabolism
EDAT- 1996/12/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - 10.1002/(SICI)1096-9896(199612)180:4<415::AID-PATH684>3.0.CO;2-A [pii]
AID - 10.1002/(SICI)1096-9896(199612)180:4<415::AID-PATH684>3.0.CO;2-A [doi]
PST - ppublish
SO  - J Pathol. 1996 Dec;180(4):415-22. doi: 
      10.1002/(SICI)1096-9896(199612)180:4<415::AID-PATH684>3.0.CO;2-A.