PMID- 9018240
OWN - NLM
STAT- MEDLINE
DCOM- 19970228
LR  - 20190914
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 3
IP  - 2
DP  - 1997 Feb
TI  - Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) 
      during primary infection demonstrated by rapid selection of CTL escape virus.
PG  - 205-11
AB  - The HIV-1-specific cytotoxic T lymphocyte (CTL) response is temporally associated 
      with the decline in viremia during primary HIV-1 infection, but definitive 
      evidence that it is of importance in virus containment has been lacking. Here we 
      show that in a patient whose early CTL response was focused on a highly 
      immunodominant epitope in gp 160, there was rapid elimination of the transmitted 
      virus strain and selection for a virus population bearing amino acid changes at a 
      single residue within this epitope, which conferred escape from recognition by 
      epitope-specific CTL. The magnitude (> 100-fold), kinetics (30-72 days from onset 
      of symptoms) and genetic pathways of virus escape from CTL pressure were 
      comparable to virus escape from antiretroviral therapy, indicating the biological 
      significance of the CTL response in vivo. One aim of HIV-1 vaccines should thus 
      be to elicit strong CTL responses against multiple codominant viral epitopes.
FAU - Borrow, P
AU  - Borrow P
AD  - Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 
      92037, USA.
FAU - Lewicki, H
AU  - Lewicki H
FAU - Wei, X
AU  - Wei X
FAU - Horwitz, M S
AU  - Horwitz MS
FAU - Peffer, N
AU  - Peffer N
FAU - Meyers, H
AU  - Meyers H
FAU - Nelson, J A
AU  - Nelson JA
FAU - Gairin, J E
AU  - Gairin JE
FAU - Hahn, B H
AU  - Hahn BH
FAU - Oldstone, M B
AU  - Oldstone MB
FAU - Shaw, G M
AU  - Shaw GM
LA  - eng
GR  - AI 09484/AI/NIAID NIH HHS/United States
GR  - AI 35467/AI/NIAID NIH HHS/United States
GR  - AI 37430/AI/NIAID NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (HIV Envelope Protein gp160)
RN  - 0 (Immunodominant Epitopes)
RN  - 0 (Oligonucleotide Probes)
SB  - IM
CIN - Nat Med. 1997 Feb;3(2):156-7. PMID: 9018232
MH  - Acquired Immunodeficiency Syndrome/immunology/*virology
MH  - HIV Envelope Protein gp160/immunology
MH  - HIV-1/*immunology
MH  - Humans
MH  - Immunodominant Epitopes/immunology
MH  - Oligonucleotide Probes
MH  - T-Lymphocytes, Cytotoxic/*immunology
MH  - Viremia/*immunology
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.1038/nm0297-205 [doi]
PST - ppublish
SO  - Nat Med. 1997 Feb;3(2):205-11. doi: 10.1038/nm0297-205.