PMID- 9020076
OWN - NLM
STAT- MEDLINE
DCOM- 19970310
LR  - 20240222
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 275
IP  - 5302
DP  - 1997 Feb 14
TI  - Isolation of putative progenitor endothelial cells for angiogenesis.
PG  - 964-7
AB  - Putative endothelial cell (EC) progenitors or angioblasts were isolated from 
      human peripheral blood by magnetic bead selection on the basis of cell surface 
      antigen expression. In vitro, these cells differentiated into ECs. In animal 
      models of ischemia, heterologous, homologous, and autologous EC progenitors 
      incorporated into sites of active angiogenesis. These findings suggest that EC 
      progenitors may be useful for augmenting collateral vessel growth to ischemic 
      tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic 
      agents, respectively, to sites of pathologic or utilitarian angiogenesis.
FAU - Asahara, T
AU  - Asahara T
AD  - Department of Medicine (Cardiology), St. Elizabeth's Medical Center, Tufts 
      University School of Medicine, 736 Cambridge Street, Boston, MA 02135, USA.
FAU - Murohara, T
AU  - Murohara T
FAU - Sullivan, A
AU  - Sullivan A
FAU - Silver, M
AU  - Silver M
FAU - van der Zee, R
AU  - van der Zee R
FAU - Li, T
AU  - Li T
FAU - Witzenbichler, B
AU  - Witzenbichler B
FAU - Schatteman, G
AU  - Schatteman G
FAU - Isner, J M
AU  - Isner JM
LA  - eng
GR  - 2824/PHS HHS/United States
GR  - 53354/PHS HHS/United States
GR  - 57516/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antigens, CD34)
RN  - 0 (Biomarkers)
RN  - 0 (Receptors, Growth Factor)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptors, Vascular Endothelial Growth Factor)
SB  - IM
MH  - Animals
MH  - Antigens, CD34/analysis
MH  - Biomarkers/analysis
MH  - Cell Differentiation
MH  - Cell Separation
MH  - Cells, Cultured
MH  - Endothelium, Vascular/chemistry/*cytology
MH  - Flow Cytometry
MH  - Hindlimb/blood supply
MH  - Humans
MH  - Ischemia/physiopathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Nude
MH  - Mice, Transgenic
MH  - *Neovascularization, Physiologic
MH  - Nitric Oxide Synthase/analysis
MH  - Rabbits
MH  - Receptor Protein-Tyrosine Kinases/analysis
MH  - Receptors, Growth Factor/analysis
MH  - Receptors, Vascular Endothelial Growth Factor
MH  - Stem Cells/chemistry/*cytology
EDAT- 1997/02/14 00:00
MHDA- 1997/02/14 00:01
CRDT- 1997/02/14 00:00
PHST- 1997/02/14 00:00 [pubmed]
PHST- 1997/02/14 00:01 [medline]
PHST- 1997/02/14 00:00 [entrez]
AID - 10.1126/science.275.5302.964 [doi]
PST - ppublish
SO  - Science. 1997 Feb 14;275(5302):964-7. doi: 10.1126/science.275.5302.964.