PMID- 9027306
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220317
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 275
IP  - 5303
DP  - 1997 Feb 21
TI  - Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman 
      Scattering.
PG  - 1102-6
AB  - Optical detection and spectroscopy of single molecules and single nanoparticles 
      have been achieved at room temperature with the use of surface-enhanced Raman 
      scattering. Individual silver colloidal nanoparticles were screened from a large 
      heterogeneous population for special size-dependent properties and were then used 
      to amplify the spectroscopic signatures of adsorbed molecules. For single 
      rhodamine 6G molecules adsorbed on the selected nanoparticles, the intrinsic 
      Raman enhancement factors were on the order of 10(14) to 10(15), much larger than 
      the ensemble-averaged values derived from conventional measurements. This 
      enormous enhancement leads to vibrational Raman signals that are more intense and 
      more stable than single-molecule fluorescence.
FAU - Nie, S
AU  - Nie S
AD  - Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.
FAU - Emory, SR
AU  - Emory SR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
EDAT- 1997/02/21 00:00
MHDA- 1997/02/21 00:01
CRDT- 1997/02/21 00:00
PHST- 1997/02/21 00:00 [pubmed]
PHST- 1997/02/21 00:01 [medline]
PHST- 1997/02/21 00:00 [entrez]
AID - 10.1126/science.275.5303.1102 [doi]
PST - ppublish
SO  - Science. 1997 Feb 21;275(5303):1102-6. doi: 10.1126/science.275.5303.1102.