PMID- 9043741
OWN - NLM
STAT- MEDLINE
DCOM- 19970514
LR  - 20190831
IS  - 0317-1671 (Print)
IS  - 0317-1671 (Linking)
VI  - 24
IP  - 1
DP  - 1997 Feb
TI  - Mechanisms of glioma invasion: role of matrix-metalloproteinases.
PG  - 3-15
AB  - One of the most lethal properties of high grade gliomas is their ability to 
      invade the surrounding normal brain tissue, as infiltrated cells often escape 
      surgical resection and inevitably lead to tumour recurrence. The consequent poor 
      prognosis and survival rate underscore the need to further understand and target 
      the cellular mechanisms that underly tumour invasiveness. Proteases which degrade 
      the surrounding stromal cells and extracellular matrix proteins have been 
      demonstrated to be critical effectors of invasion for tumours of both central and 
      peripheral origin. Within the nervous system, the role of metalloproteinases as 
      well as other classes of proteases in mediating the invasive phenotype of high 
      grade gliomas has been an intense area of research. We present in this article a 
      review of this literature and address the possibility that these proteases and 
      the biochemical pathways that regulate their expression, such as protein kinase 
      C, may represent potential targets in the therapy of high grade gliomas.
FAU - Uhm, J H
AU  - Uhm JH
AD  - Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill 
      University, Canada.
FAU - Dooley, N P
AU  - Dooley NP
FAU - Villemure, J G
AU  - Villemure JG
FAU - Yong, V W
AU  - Yong VW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Can J Neurol Sci
JT  - The Canadian journal of neurological sciences. Le journal canadien des sciences 
      neurologiques
JID - 0415227
RN  - EC 3.4.24.- (Metalloendopeptidases)
SB  - IM
MH  - Animals
MH  - Brain Neoplasms/*enzymology/*pathology
MH  - Extracellular Matrix/*enzymology
MH  - Glioma/*enzymology/*pathology
MH  - Humans
MH  - Metalloendopeptidases/*metabolism
RF  - 143
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
AID - 10.1017/s0317167100021028 [doi]
PST - ppublish
SO  - Can J Neurol Sci. 1997 Feb;24(1):3-15. doi: 10.1017/s0317167100021028.