PMID- 9046034
OWN - NLM
STAT- MEDLINE
DCOM- 19970623
LR  - 20220316
IS  - 0300-8177 (Print)
IS  - 0300-8177 (Linking)
VI  - 166
IP  - 1-2
DP  - 1997 Jan
TI  - Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma 
      longa) in streptozotocin induced diabetic rats.
PG  - 169-75
AB  - Streptozotocin-induced diabetic rats were maintained on 0.5% curcumin containing 
      diet for 8 weeks. Blood cholesterol was lowered significantly by dietary curcumin 
      in these diabetic animals. Cholesterol decrease was exclusively from LDL-VLDL 
      fraction. Significant decrease in blood triglyceride and phospholipids was also 
      brought about by dietary curcumin in diabetic rats. In a parallel study, wherein 
      diabetic animals were maintained on a high cholesterol diet, the extents of 
      hypercholesterolemia and phospholipidemia were still higher compared to those 
      maintained on control diet. Curcumin exhibited lowering of cholesterol and 
      phospholipid in these animals also. Liver cholesterol, triglyceride and 
      phospholipid contents were elevated under diabetic conditions. Dietary curcumin 
      showed a distinct tendency to counter these changes in lipid fractions of liver. 
      This effect of curcumin was also seen in diabetic animals maintained on high 
      cholesterol diet. Dietary curcumin also showed significant countering of renal 
      cholesterol and triglycerides elevated in diabetic rats. In order to understand 
      the mechanism of hypocholesterolemic action of dietary curcumin, activities of 
      hepatic cholesterol-7a-hydroxylase and HMG CoA reductase were measured. Hepatic 
      cholesterol-7a-hydroxylase activity was markedly higher in curcumin fed diabetic 
      animals suggesting a higher rate of cholesterol catabolism.
FAU - Babu, P S
AU  - Babu PS
AD  - Department of Biochemistry and Nutrition, Central Food Technological Research 
      Institute, Mysore, India.
FAU - Srinivasan, K
AU  - Srinivasan K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Cholesterol, Dietary)
RN  - 0 (Hypolipidemic Agents)
RN  - 0 (Lipids)
RN  - 5W494URQ81 (Streptozocin)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Cholesterol, Dietary/pharmacology
MH  - Curcumin/*pharmacology
MH  - Diabetes Mellitus, Experimental/*drug therapy/metabolism
MH  - Hypolipidemic Agents/*pharmacology
MH  - Lipid Metabolism
MH  - Lipids/blood
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Streptozocin
MH  - Tissue Distribution
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1023/a:1006819605211 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 1997 Jan;166(1-2):169-75. doi: 10.1023/a:1006819605211.