PMID- 9053312
OWN - NLM
STAT- MEDLINE
DCOM- 19970313
LR  - 20220215
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 124
IP  - 2
DP  - 1997 Jan
TI  - Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in 
      the developing mouse retina.
PG  - 363-71
AB  - We show that Sonic hedgehog and patched are expressed in adjacent domains in the 
      developing mouse retina. Treatment of cultures of perinatal mouse retinal cells 
      with the amino-terminal fragment of Sonic hedgehog protein results in an increase 
      in the proportion of cells that incorporate bromodeoxuridine, in total cell 
      numbers, and in rod photoreceptors, amacrine cells and Muller glial cells, 
      suggesting that Sonic hedgehog promotes the proliferation of retinal precursor 
      cells. These findings suggest that hedgehog and patched are part of a conserved 
      signalling pathway in retinal development in mammals and insects.
FAU - Jensen, A M
AU  - Jensen AM
AD  - MRC Developmental Neurobiology Programme, University College London, UK.
FAU - Wallace, V A
AU  - Wallace VA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Drosophila Proteins)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Insect Hormones)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Trans-Activators)
RN  - 0 (Transforming Growth Factor alpha)
RN  - 0 (ptc protein, Drosophila)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - 1F7A44V6OU (Colforsin)
RN  - E0399OZS9N (Cyclic AMP)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Bromodeoxyuridine
MH  - Cell Differentiation
MH  - Cell Division/drug effects
MH  - Cells, Cultured
MH  - Colforsin/pharmacology
MH  - Crosses, Genetic
MH  - Cyclic AMP/metabolism
MH  - *Drosophila Proteins
MH  - Embryonic Induction
MH  - Female
MH  - Fibroblast Growth Factor 2/analysis/biosynthesis
MH  - *Gene Expression Regulation, Developmental
MH  - Hedgehog Proteins
MH  - In Situ Hybridization
MH  - Insect Hormones/*biosynthesis
MH  - Male
MH  - Membrane Proteins/*biosynthesis
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Neurons/cytology/drug effects/*physiology
MH  - *Protein Biosynthesis
MH  - Proteins/analysis
MH  - Receptors, Cell Surface/biosynthesis
MH  - Retina/cytology/embryology/*physiology
MH  - Stem Cells/cytology/physiology
MH  - *Trans-Activators
MH  - Transcription, Genetic
MH  - Transforming Growth Factor alpha/analysis/biosynthesis
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1242/dev.124.2.363 [doi]
PST - ppublish
SO  - Development. 1997 Jan;124(2):363-71. doi: 10.1242/dev.124.2.363.