PMID- 9065402
OWN - NLM
STAT- MEDLINE
DCOM- 19970422
LR  - 20230108
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 275
IP  - 5307
DP  - 1997 Mar 21
TI  - Activation of beta-catenin-Tcf signaling in colon cancer by mutations in 
      beta-catenin or APC.
PG  - 1787-90
AB  - Inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene 
      initiates colorectal neoplasia. One of the biochemical activities associated with 
      the APC protein is down-regulation of transcriptional activation mediated by 
      beta-catenin and T cell transcription factor 4 (Tcf-4). The protein products of 
      mutant APC genes present in colorectal tumors were found to be defective in this 
      activity. Furthermore, colorectal tumors with intact APC genes were found to 
      contain activating mutations of beta-catenin that altered functionally 
      significant phosphorylation sites. These results indicate that regulation of 
      beta-catenin is critical to APC's tumor suppressive effect and that this 
      regulation can be circumvented by mutations in either APC or beta-catenin.
FAU - Morin, P J
AU  - Morin PJ
AD  - Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond 
      Street, Baltimore, MD 21231, USA.
FAU - Sparks, A B
AU  - Sparks AB
FAU - Korinek, V
AU  - Korinek V
FAU - Barker, N
AU  - Barker N
FAU - Clevers, H
AU  - Clevers H
FAU - Vogelstein, B
AU  - Vogelstein B
FAU - Kinzler, K W
AU  - Kinzler KW
LA  - eng
GR  - CA57345/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Adenomatous Polyposis Coli Protein)
RN  - 0 (CTNNB1 protein, human)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (TCF Transcription Factors)
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
RN  - 0 (Transcription Factors)
RN  - 0 (beta Catenin)
SB  - IM
CIN - Science. 1997 Mar 21;275(5307):1752-3. PMID: 9122680
MH  - Adenomatous Polyposis Coli Protein
MH  - Colonic Neoplasms/*genetics/metabolism
MH  - Cytoskeletal Proteins/*genetics/*metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - *Genes, APC
MH  - Genes, Reporter
MH  - Germ-Line Mutation
MH  - Humans
MH  - Mutation
MH  - Phosphorylation
MH  - Signal Transduction
MH  - TCF Transcription Factors
MH  - *Trans-Activators
MH  - Transcription Factor 7-Like 2 Protein
MH  - Transcription Factors/*metabolism
MH  - *Transcription, Genetic
MH  - Transfection
MH  - Tumor Cells, Cultured
MH  - beta Catenin
EDAT- 1997/03/21 00:00
MHDA- 1997/03/21 00:01
CRDT- 1997/03/21 00:00
PHST- 1997/03/21 00:00 [pubmed]
PHST- 1997/03/21 00:01 [medline]
PHST- 1997/03/21 00:00 [entrez]
AID - 10.1126/science.275.5307.1787 [doi]
PST - ppublish
SO  - Science. 1997 Mar 21;275(5307):1787-90. doi: 10.1126/science.275.5307.1787.