PMID- 9065537
OWN - NLM
STAT- MEDLINE
DCOM- 19970328
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 48
IP  - 3
DP  - 1997 Mar
TI  - Risk of Alzheimer's disease and duration of NSAID use.
PG  - 626-32
AB  - In a longitudinal study of 1,686 participants in the Baltimore Longitudinal Study 
      of Aging, we examined whether the risk of Alzheimer's disease (AD) was reduced 
      among reported users of aspirin or other nonsteroidal anti-inflammatory drugs 
      (NSAIDs). In addition, we examined use of acetaminophen, a pain-relief medication 
      with little or no anti-inflammatory activity, to assess the specificity of the 
      association between AD risk and self-reported medications. Information on use of 
      medications was collected during each biennial examination between 1980 and 1995. 
      The relative risk (RR) for AD decreased with increasing duration of NSAID use. 
      Among those with 2 or more years of reported NSAID use, the RR was 0.40 (95% 
      confidence interval [CI]: 0.19-0.84) compared with 0.65 (95% CI: 0.33-1.29) for 
      those with less than 2 years of NSAID use. The overall RR for AD among aspirin 
      users was 0.74 (95% CI: 0.46-1.18), and no trend of decreasing risk of AD was 
      observed with increasing duration of aspirin use. No association was found 
      between AD risk and use of acetaminophen (RR = 1.35; 95% CI: 0.79-2.30), and 
      there was no trend of decreasing risk with increasing duration of use. These 
      findings are consistent with evidence from cross-sectional studies indicating 
      protection against AD risk among NSAID users and with evidence suggesting that 
      one stage of the pathophysiology leading to AD is characterized by an 
      inflammatory process.
FAU - Stewart, W F
AU  - Stewart WF
AD  - Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD 
      21205, USA.
FAU - Kawas, C
AU  - Kawas C
FAU - Corrada, M
AU  - Corrada M
FAU - Metter, E J
AU  - Metter EJ
LA  - eng
GR  - R01AG08325/AG/NIA NIH HHS/United States
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 362O9ITL9D (Acetaminophen)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
CIN - ACP J Club. 1997 Sep-Oct;127(2):46-7
CIN - Neurology. 1998 Aug;51(2):652. PMID: 9710076
MH  - Acetaminophen/therapeutic use
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*prevention & control
MH  - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage
MH  - Aspirin/therapeutic use
MH  - Confidence Intervals
MH  - Drug Administration Schedule
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Assessment
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - 10.1212/wnl.48.3.626 [doi]
PST - ppublish
SO  - Neurology. 1997 Mar;48(3):626-32. doi: 10.1212/wnl.48.3.626.