PMID- 9065558
OWN - NLM
STAT- MEDLINE
DCOM- 19970328
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 48
IP  - 3
DP  - 1997 Mar
TI  - The beta APP717 Alzheimer mutation increases the percentage of plasma 
      amyloid-beta protein ending at A beta42(43).
PG  - 741-5
AB  - We measured plasma levels of amyloid beta protein (A beta) ending at positions 40 
      (A beta40) and 42(43) [A beta42(43)] in six carriers of beta APP717 (Val to Ile) 
      mutation linked to familial Alzheimer's disease (FAD) as well as in patients with 
      sporadic AD (sAD) and controls. The percentage and the level of A beta42(43) were 
      significantly higher in carriers of beta APP717 mutation relative to sAD, whereas 
      A beta40 levels were decreased. In contrast, A beta levels and ratios were at 
      similar levels in sAD, regardless of the stage of the disease, compared with 
      non-AD neurologic disease controls and nondemented control individuals. These 
      results suggest that the reported increase in the percentage of A beta42(43) 
      secretion in transfected cells with beta APP717 mutant genes actually takes place 
      in the bodies of carriers of beta APP717 mutation, and that plasma A beta could 
      be used as an indicator of the alterations of beta APP/A beta metabolism in 
      subtypes of AD.
FAU - Kosaka, T
AU  - Kosaka T
AD  - Department of Neuropathology, Faculty of Pharmaceutical Sciences, University of 
      Tokyo, Japan.
FAU - Imagawa, M
AU  - Imagawa M
FAU - Seki, K
AU  - Seki K
FAU - Arai, H
AU  - Arai H
FAU - Sasaki, H
AU  - Sasaki H
FAU - Tsuji, S
AU  - Tsuji S
FAU - Asami-Odaka, A
AU  - Asami-Odaka A
FAU - Fukushima, T
AU  - Fukushima T
FAU - Imai, K
AU  - Imai K
FAU - Iwatsubo, T
AU  - Iwatsubo T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*blood/*genetics
MH  - Amyloid beta-Peptides/*blood/*genetics
MH  - Chromatography, High Pressure Liquid
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Genetic Markers
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Point Mutation
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - 10.1212/wnl.48.3.741 [doi]
PST - ppublish
SO  - Neurology. 1997 Mar;48(3):741-5. doi: 10.1212/wnl.48.3.741.