PMID- 9108152
OWN - NLM
STAT- MEDLINE
DCOM- 19970529
LR  - 20211209
IS  - 0305-1048 (Print)
IS  - 1362-4962 (Electronic)
IS  - 0305-1048 (Linking)
VI  - 25
IP  - 9
DP  - 1997 May 1
TI  - The winged-helix transcription factor Trident is expressed in cycling cells.
PG  - 1715-9
AB  - We describe the cloning and characterization of Trident , a novel member of the 
      fork head/winged-helix family, from murine thymus. In the mouse embryo, the gene 
      was expressed in all tissues, whereas in adult mice expression was only detected 
      in the thymus. Further analysis revealed that Trident expression strictly 
      correlated with cell cycling, independent of cell type. Timing of [3H]thymidine 
      incorporation showed that mRNA and protein expression were strongly upregulated 
      upon entry into the S phase of the cell cycle. Moreover, the protein was 
      phosphorylated in M phase. PCR-mediated selection of optimal binding sites 
      yielded a consensus motif resembling that of other family members. These results 
      identify Trident as a transcription factor, which is likely involved in cell 
      cycle-specific gene regulation.
FAU - Korver, W
AU  - Korver W
AD  - Department of Immunology, University Hospital Utrecht, PO Box 85500, 3508 GA, 
      Utrecht, The Netherlands. w.korver@lab.azu.nl
FAU - Roose, J
AU  - Roose J
FAU - Clevers, H
AU  - Clevers H
LA  - eng
SI  - GENBANK/Y11245
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Forkhead Box Protein M1)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxm1 protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Binding Sites
MH  - Cell Line
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - Forkhead Box Protein M1
MH  - Forkhead Transcription Factors
MH  - Mice
MH  - *Mitosis
MH  - Molecular Sequence Data
MH  - Phosphorylation
MH  - Rats
MH  - Sequence Homology, Amino Acid
MH  - Transcription Factors/*genetics/metabolism
MH  - Transcriptional Activation
PMC - PMC146663
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
PMCR- 1997/05/01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
PHST- 1997/05/01 00:00 [pmc-release]
AID - gka312 [pii]
AID - 10.1093/nar/25.9.1715 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 1997 May 1;25(9):1715-9. doi: 10.1093/nar/25.9.1715.