PMID- 9121588
OWN - NLM
STAT- MEDLINE
DCOM- 19970422
LR  - 20220409
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 386
IP  - 6625
DP  - 1997 Apr 10
TI  - Genetic instability in colorectal cancers.
PG  - 623-7
AB  - It has long been considered that genetic instability is an integral component of 
      human neoplasia. In a small fraction of tumours, mismatch repair deficiency leads 
      to a microsatellite instability at the nucleotide sequence level. In other 
      tumours, an abnormal chromosome number (aneuploidy) has suggested an instability, 
      but the nature and magnitude of the postulated instability is a matter of 
      conjecture. We show here that colorectal tumours without microsatellite 
      instability exhibit a striking defect in chromosome segregation, resulting in 
      gains or losses in excess of 10(-2) per chromosome per generation. This form of 
      chromosomal instability reflected a continuing cellular defect that persisted 
      throughout the lifetime of the tumour cell and was not simply related to 
      chromosome number. While microsatellite instability is a recessive trait, 
      chromosomal instability appeared to be dominant. These data indicate that 
      persistent genetic instability may be critical for the development of all 
      colorectal cancers, and that such instability can arise through two distinct 
      pathways.
FAU - Lengauer, C
AU  - Lengauer C
AD  - The Howard Hughes Medical Institute and The Johns Hopkins Oncology Center, 
      Baltimore, Maryland 21231, USA.
FAU - Kinzler, K W
AU  - Kinzler KW
FAU - Vogelstein, B
AU  - Vogelstein B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
MH  - *Aneuploidy
MH  - Cell Fusion
MH  - Cell Survival
MH  - Colorectal Neoplasms/*genetics
MH  - Genes, Tumor Suppressor
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Tumor Cells, Cultured
EDAT- 1997/04/10 00:00
MHDA- 1997/04/10 00:01
CRDT- 1997/04/10 00:00
PHST- 1997/04/10 00:00 [pubmed]
PHST- 1997/04/10 00:01 [medline]
PHST- 1997/04/10 00:00 [entrez]
AID - 10.1038/386623a0 [doi]
PST - ppublish
SO  - Nature. 1997 Apr 10;386(6625):623-7. doi: 10.1038/386623a0.