PMID- 9126051
OWN - NLM
STAT- MEDLINE
DCOM- 19970516
LR  - 20220331
IS  - 0006-8950 (Print)
IS  - 0006-8950 (Linking)
VI  - 120 ( Pt 3)
DP  - 1997 Mar
TI  - Axonal damage in acute multiple sclerosis lesions.
PG  - 393-9
AB  - One of the histological hallmarks of early multiple sclerosis lesions is primary 
      demyelination, with myelin destruction and relative sparing of axons. On the 
      other hand, it is widely accepted that axonal loss occurs in, and is responsible 
      for, the permanent disability characterizing the later chronic progressive stage 
      of the disease. In this study, we have used an antibody against amyloid precursor 
      protein, known to be a sensitive marker of axonal damage in a number of other 
      contexts, in immunocytochemical experiments on paraffin embedded multiple 
      sclerosis lesions of varying ages in order to see at which stage of the disease 
      axonal damage, in addition to demyelination, occurs and may thus contribute to 
      the development of disability in patients. The results show the expression of 
      amyloid precursor protein in damaged axons within acute multiple sclerosis 
      lesions, and in the active borders of less acute lesions. This observation may 
      have implications for the design and timing of therapeutic intervention, one of 
      the most important aims of which must be the reduction of permanent disability.
FAU - Ferguson, B
AU  - Ferguson B
AD  - Department of Pharmacology, Oxford University, UK.
FAU - Matyszak, M K
AU  - Matyszak MK
FAU - Esiri, M M
AU  - Esiri MM
FAU - Perry, V H
AU  - Perry VH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Brain
JT  - Brain : a journal of neurology
JID - 0372537
RN  - 0 (Amyloid beta-Protein Precursor)
SB  - IM
MH  - Acute Disease
MH  - Amyloid beta-Protein Precursor/analysis
MH  - Axons/*ultrastructure
MH  - Humans
MH  - Multiple Sclerosis/metabolism/*pathology
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - 10.1093/brain/120.3.393 [doi]
PST - ppublish
SO  - Brain. 1997 Mar;120 ( Pt 3):393-9. doi: 10.1093/brain/120.3.393.