PMID- 9127691
OWN - NLM
STAT- MEDLINE
DCOM- 19970703
LR  - 20190905
IS  - 0009-9120 (Print)
IS  - 0009-9120 (Linking)
VI  - 30
IP  - 2
DP  - 1997 Mar
TI  - Resveratrol: a molecule whose time has come? And gone?
PG  - 91-113
AB  - OBJECTIVES: Resveratrol (3,5,4'-trihydroxystilbene) is the parent compound of a 
      family of molecules, including glucosides and polymers, existing in cis and trans 
      configurations in a narrow range of spermatophytes of which vines, peanuts and 
      pines are the prime representatives. Its synthesis from p-coumaroyl CoA and 
      malonyl CoA is induced by stress, injury, infection or UV-irradiation, and it is 
      classified as a phytoalexin anti-fungicide conferring disease resistance in the 
      plant kingdom. RESULTS: In vitro, ex vivo and animal experiments have shown that 
      it possesses many biological attributes that favour protection against 
      atherosclerosis, including antioxidant activity, modulation of hepatic 
      apolipoprotein and lipid synthesis, inhibition of platelet aggregation as well as 
      the production of pro-atherogenic eicosanoids by human platelets and neutrophils. 
      Red wine represents its main source in the human diet, and it has been proposed 
      as a major constituent of the polyphenol fraction to which the health benefits of 
      red wine consumption have been attributed. CONCLUSIONS: The past several years 
      have witnessed intense research devoted to its measurement in wine and the 
      factors likely to promote its enrichment in this beverage. Up to the present, 
      conclusive evidence for its absorption by human subjectsin biologically 
      significant amounts is lacking, and it is questionable (but not yetexcluded) that 
      its powerful and beneficial in vitro activities are reproduced as a consequence 
      of sustained moderate red wine consumption.
FAU - Soleas, G J
AU  - Soleas GJ
AD  - Department of Clinical Biochemistry, University of Toronto, Banting Institute, 
      Ontario, Canada.
FAU - Diamandis, E P
AU  - Diamandis EP
FAU - Goldberg, D M
AU  - Goldberg DM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Stilbenes)
RN  - EC 2.3.- (Acyltransferases)
RN  - EC 2.3.1.- (resveratrol synthase)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Acyltransferases/chemistry/*genetics/physiology
MH  - Chromatography/methods
MH  - Fruit/chemistry/drug effects
MH  - Fungi/drug effects
MH  - Humans
MH  - Lipid Metabolism
MH  - Male
MH  - Mitosporic Fungi/drug effects
MH  - Platelet Aggregation/drug effects
MH  - Platelet Aggregation Inhibitors/chemistry/pharmacology
MH  - Resveratrol
MH  - *Stilbenes/chemistry/isolation & purification/metabolism/pharmacology/therapeutic 
      use
MH  - Wine/*analysis
RF  - 183
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - S0009-9120(96)00155-5 [pii]
AID - 10.1016/s0009-9120(96)00155-5 [doi]
PST - ppublish
SO  - Clin Biochem. 1997 Mar;30(2):91-113. doi: 10.1016/s0009-9120(96)00155-5.