PMID- 9177350
OWN - NLM
STAT- MEDLINE
DCOM- 19970623
LR  - 20220309
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 387
IP  - 6633
DP  - 1997 Jun 5
TI  - Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation.
PG  - 611-7
AB  - Chemokines are small secreted proteins that stimulate the directional migration 
      of leukocytes and mediate inflammation. During screening of a murine choroid 
      plexus complementary DNA library, we identified a new chemokine, designated 
      neurotactin. Unlike other chemokines, neurotactin has a unique cysteine pattern, 
      Cys-X-X-X-Cys, and is predicted to be a type 1 membrane protein. Full-length 
      recombinant neurotactin is localized on the surface of transfected 293 cells. 
      Recombinant neurotactin containing the chemokine domain is chemotactic for 
      neutrophils both in vitro and in vivo. Neurotactin messenger RNA is predominantly 
      expressed in normal murine brain and its protein expression in activated brain 
      microglia is upregulated in mice with experimental autoimmune encephalomyelitis, 
      as well as in mice treated with lipopolysaccharide. Distinct from all other 
      chemokine genes, the neurotactin gene is localized to human chromosome 16q. 
      Consequently we propose that neurotactin represents a new delta-chemokine family 
      and that it may play a role in brain inflammation processes.
FAU - Pan, Y
AU  - Pan Y
AD  - Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA. 
      pan@mpi.com
FAU - Lloyd, C
AU  - Lloyd C
FAU - Zhou, H
AU  - Zhou H
FAU - Dolich, S
AU  - Dolich S
FAU - Deeds, J
AU  - Deeds J
FAU - Gonzalo, J A
AU  - Gonzalo JA
FAU - Vath, J
AU  - Vath J
FAU - Gosselin, M
AU  - Gosselin M
FAU - Ma, J
AU  - Ma J
FAU - Dussault, B
AU  - Dussault B
FAU - Woolf, E
AU  - Woolf E
FAU - Alperin, G
AU  - Alperin G
FAU - Culpepper, J
AU  - Culpepper J
FAU - Gutierrez-Ramos, J C
AU  - Gutierrez-Ramos JC
FAU - Gearing, D
AU  - Gearing D
LA  - eng
SI  - GENBANK/AF010586
GR  - 087618/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Chemokines)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Nrt protein, Drosophila)
RN  - 0 (Recombinant Proteins)
RN  - K848JZ4886 (Cysteine)
SB  - IM
EIN - Nature 1997 Sep 4;389(6646):100
MH  - Animals
MH  - Brain/immunology/*metabolism
MH  - Cell Line
MH  - Cell Membrane/metabolism
MH  - Chemokines/biosynthesis/genetics/*physiology
MH  - Chemotaxis
MH  - Chromosomes, Human, Pair 16
MH  - Cysteine/analysis
MH  - *Drosophila Proteins
MH  - Encephalitis/*metabolism
MH  - Escherichia coli
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Lipopolysaccharides
MH  - Membrane Glycoproteins/biosynthesis/genetics/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Recombinant Proteins
MH  - Sequence Homology, Amino Acid
MH  - *Up-Regulation
EDAT- 1997/06/05 00:00
MHDA- 2001/03/23 10:01
CRDT- 1997/06/05 00:00
PHST- 1997/06/05 00:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1997/06/05 00:00 [entrez]
AID - 10.1038/42491 [doi]
PST - ppublish
SO  - Nature. 1997 Jun 5;387(6633):611-7. doi: 10.1038/42491.