PMID- 9212098
OWN - NLM
STAT- MEDLINE
DCOM- 19970804
LR  - 20230120
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 3
IP  - 7
DP  - 1997 Jul
TI  - Human acute myeloid leukemia is organized as a hierarchy that originates from a 
      primitive hematopoietic cell.
PG  - 730-7
AB  - On the subject of acute myeloid leukemia (AML), there is little consensus about 
      the target cell within the hematopoietic stem cell hierarchy that is susceptible 
      to leukemic transformation, or about the mechanism that underlies the phenotypic, 
      genotypic and clinical heterogeneity. Here we demonstrate that the cell capable 
      of initiating human AML in non-obese diabetic mice with severe combined 
      immunodeficiency disease (NOD/SCID mice) - termed the SCID leukemia-initiating 
      cell, or SL-IC - possesses the differentiative and proliferative capacities and 
      the potential for self-renewal expected of a leukemic stem cell. The SL-ICs from 
      all subtypes of AML analyzed, regardless of the heterogeneity in maturation 
      characteristics of the leukemic blasts, were exclusively CD34++ CD38-, similar to 
      the cell-surface phenotype of normal SCID-repopulating cells, suggesting that 
      normal primitive cells, rather than committed progenitor cells, are the target 
      for leukemic transformation. The SL-ICs were able to differentiate in vivo into 
      leukemic blasts, indicating that the leukemic clone is organized as a hierarchy.
FAU - Bonnet, D
AU  - Bonnet D
AD  - Department of Genetics, Research Institute, Hospital for Sick Children, 
      University of Toronto, Ontario, Canada.
FAU - Dick, J E
AU  - Dick JE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD34)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Membrane Glycoproteins)
RN  - EC 3.2.2.- (N-Glycosyl Hydrolases)
RN  - EC 3.2.2.5 (ADP-ribosyl Cyclase)
RN  - EC 3.2.2.5 (CD38 protein, human)
RN  - EC 3.2.2.5 (Cd38 protein, mouse)
RN  - EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
SB  - IM
MH  - ADP-ribosyl Cyclase
MH  - ADP-ribosyl Cyclase 1
MH  - Acute Disease
MH  - Aged
MH  - Animals
MH  - *Antigens, CD
MH  - Antigens, CD34
MH  - Antigens, Differentiation
MH  - Cell Differentiation
MH  - Cell Division
MH  - *Cell Transformation, Neoplastic
MH  - Clone Cells
MH  - Disease Models, Animal
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation
MH  - Hematopoietic Stem Cells/*pathology
MH  - Humans
MH  - Immunophenotyping
MH  - Leukemia, Monocytic, Acute/*pathology
MH  - Leukemia, Myeloid, Acute/*pathology
MH  - Leukemia, Myelomonocytic, Acute/*pathology
MH  - Male
MH  - Membrane Glycoproteins
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Mice, SCID
MH  - Middle Aged
MH  - N-Glycosyl Hydrolases
MH  - Neoplasm Transplantation
EDAT- 1997/07/01 00:00
MHDA- 1997/07/01 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/07/01 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
AID - 10.1038/nm0797-730 [doi]
PST - ppublish
SO  - Nat Med. 1997 Jul;3(7):730-7. doi: 10.1038/nm0797-730.